Abnormal plasma lipids profile in women with post-adolescent acne

Abstract

IntroductionAcne vulgaris is a multifactorial chronic inflammatory disease that is increasingly recognized in adult women.AimTo investigate a relationship between plasma lipids profile and acne in women and a correlation between selected clinical features of acne (severity, age of onset, location of lesions and the presence of comedones) and lipids profile.Material and methodsSixty-four adult women with post-adolescent acne and 20 healthy controls were included in the study. Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were determined in all the subjects.ResultsAdult women with acne had statistically significantly increased levels of TC, TG and LDL-C compared to healthy controls (p < 0.05). The level of HDL-C did not differ between the two groups. There was no relationship between higher levels of TC, TG and LDL-C and a clinical picture of acne.ConclusionsAcne in adult women is likely to be associated with increased levels of TC, TG and LDL-C. This abnormality seems to be important in the pathogenesis of adult acne and could be a result of high fatty acid diet. Performing a lipid profile examination in women with acne should be taken into account when screening patients and followed by appropriate dietary recommendations.

Biochemical and hormonal abnormalities in adult female acne

“…We did not find any statistically significant association between acne severity and lipid profile. Romanska‐Gocka et al 29 and da Cunha et al 6 in their studies reported no association between acne severity and lipid profile. Our results were consistent with their results.…”

“…Our results were consistent with their results. However, both these studies included patients with age ≥20 years 6,29 …”

Influence of RETN, IL‐1, and IL‐6 gene polymorphisms on the risk of acne vulgaris in the Chinese population

“…Several studies have established the association between resistin secretion and the profile of blood lipid (an important source of substrate for the synthesis of sebaceous lipids), through which resistin can indirectly regulate the secretion of sebum. [29][30][31] Changes in sebum activity, especially sebum components and oxidant/antioxidant fatty acid ratio, are clearly correlated with acne inflammation. 32 Keratinocytes and sebocytes act as immuneactive cells that can be activated by P. acnes via TLR to produce pro-inflammatory cytokines.…”

“…Resistin expressed in sebocytes is thought to affect sebum production. Several studies have established the association between resistin secretion and the profile of blood lipid (an important source of substrate for the synthesis of sebaceous lipids), through which resistin can indirectly regulate the secretion of sebum 29–31 . Changes in sebum activity, especially sebum components and oxidant/antioxidant fatty acid ratio, are clearly correlated with acne inflammation 32 …”

Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy-related skin barrier weakness

“…Therefore, we speculate that due to changes in ostrogen during pregnancy, there is a decrease in SSL secretion and weakening of the skin barrier. However, some epidemiological investigation 4 , 36 – 38 have found that acne is also a common condition during pregnancy. It is worth noting that acne occurs most often in the third trimester of pregnancy due to increased sebum secretion from maternal androgens, which does not contradict our results (the sampling population was women in the second trimester of pregnancy).…”