Abnormal plasma levels of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa

Role of essential fatty acids in the function of the developing nervous system

“…Retinitis pigmentosa. We and others have observed abnormalities in DHA metabolism in patients with RP (72)(73)(74)(79)(80)(81)(82)(83). RP and associated retinal degenerations are characterized by progressive night blindness and visual field constriction resulting from photoreceptor degeneration.…”

Role of essential fatty acids in the function of the developing nervous system

“…Retinitis pigmentosa. We and others have observed abnormalities in DHA metabolism in patients with RP (72)(73)(74)(79)(80)(81)(82)(83). RP and associated retinal degenerations are characterized by progressive night blindness and visual field constriction resulting from photoreceptor degeneration.…”

The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N‐Methyl‐N‐Nitrosourea‐Induced Photoreceptor Cell Lesion in Rats

“…DHA seems to act as a trophic molecule in photoreceptor survival both in vivo and in vitro [24]. Some studies have found lower DHA content in an RP animal model and RP patients [25, 26]. DHA supplementation of the diet of SD rats with retinal photoreceptor apoptosis induced by MNU both delayed the onset of photoreceptor cell apoptosis and suppressed the progression of retinopathy [24, 27].…”

Lipidomic analysis of the retina in a rat model of Smith–Lemli–Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species

“…1998) is dependent on a maternal supply of n3 fatty acids. Also, humans and dogs with inherited retinal degenerations have reduced plasma levels of n3 polyunsaturated fatty acids (Anderson et al. 1987, 1991).…”

Role of essential fatty acids in the function of the developing nervous system

“…Retinitis pigmentosa. We and others have observed abnormalities in DHA metabolism in patients with RP (72)(73)(74)(79)(80)(81)(82)(83). RP and associated retinal degenerations are characterized by progressive night blindness and visual field constriction resulting from photoreceptor degeneration.…”

The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N‐Methyl‐N‐Nitrosourea‐Induced Photoreceptor Cell Lesion in Rats

“…DHA seems to act as a trophic molecule in photoreceptor survival both in vivo and in vitro [24]. Some studies have found lower DHA content in an RP animal model and RP patients [25, 26]. DHA supplementation of the diet of SD rats with retinal photoreceptor apoptosis induced by MNU both delayed the onset of photoreceptor cell apoptosis and suppressed the progression of retinopathy [24, 27].…”

Lipidomic analysis of the retina in a rat model of Smith–Lemli–Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species

“…1998) is dependent on a maternal supply of n3 fatty acids. Also, humans and dogs with inherited retinal degenerations have reduced plasma levels of n3 polyunsaturated fatty acids (Anderson et al. 1987, 1991).…”

Role of essential fatty acids in the function of the developing nervous system

“…Retinitis pigmentosa. We and others have observed abnormalities in DHA metabolism in patients with RP (72)(73)(74)(79)(80)(81)(82)(83). RP and associated retinal degenerations are characterized by progressive night blindness and visual field constriction resulting from photoreceptor degeneration.…”

The Comparative Protective Effects of Ganoderma Spores Lipid and Fish Oil on N‐Methyl‐N‐Nitrosourea‐Induced Photoreceptor Cell Lesion in Rats

“…DHA seems to act as a trophic molecule in photoreceptor survival both in vivo and in vitro [24]. Some studies have found lower DHA content in an RP animal model and RP patients [25, 26]. DHA supplementation of the diet of SD rats with retinal photoreceptor apoptosis induced by MNU both delayed the onset of photoreceptor cell apoptosis and suppressed the progression of retinopathy [24, 27].…”

Lipidomic analysis of the retina in a rat model of Smith–Lemli–Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species

“…1998) is dependent on a maternal supply of n3 fatty acids. Also, humans and dogs with inherited retinal degenerations have reduced plasma levels of n3 polyunsaturated fatty acids (Anderson et al. 1987, 1991).…”