Abnormal Left Ventricular Global Longitudinal Strain By Speckle Tracking Echocardiography in COVID-19 Patients

Croft, Lori B.; Krishnamoorthy, Parasuram; Ro, Richard; Anastasius, Malcolm; Zhao, Wenli; Buckley, Samantha; Goldman, Martin E.; Argulian, Edgar; Sharma, Samin K.; Kini, Annapoorna

doi:10.2217/fca-2020-0121

Cited by 40 publications

(54 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These abovementioned findings were similar with the results of our study. Different from our study, Krishnamoorthy et al reported right ventricular dysfunction in 41.7% of the patients and left ventricular dysfunction in 58.3% via using two-dimensional speckle-tracking echocardiography [ 39 ]. It was found that right ventricular longitudinal strain was a strong predictor of mortality in COVID-19 patients [ 40 ].…”

Section: Discussioncontrasting

confidence: 91%

The effect of moderate and severe COVID-19 pneumonia on short-term right ventricular functions: a prospective observational single pandemic center analysis

Günay

Demiröz

Kahyaoğlu

et al. 2021

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

It has been reported that myocardial damage and heart failure are more common in COVID-19 patients with severe symptoms. The aim of our study was to measure the right ventricular functions of COVID-19 patients 30 days after their discharge, and compare them to the right ventricular functions of healthy volunteers. Fifty one patients with COVID-19 and 32 healthy volunteers who underwent echocardiographic examinations were enrolled in our study. 29 patients were treated for severe and 22 patients were treated for moderate COVID-19 pneumonia. The study was conducted prospectively, in a single center, between 15 May 2020 and 15 July 2020. We analyzed the right ventricular functions of the patients using conventional techniques and two-dimensional speckle-tracking. Right ventricular end-diastolic and end-systolic area were statistically higher than control group. The right ventricular fractional area change (RVFAC) was significantly lesser in the patient group compared to the control group. Tricuspid annular plane systolic motion (TAPSE) was within normal limits in both groups, it was lower in the patient group compared to the control group. Pulmonary artery pressure was found to be significantly higher in the patient group. Right ventricular global longitudinal strain (RV-GLS) was lesser than the control group (− 15.7 [(− 12.6)–(− 18.7)] vs. − 18.1 [(− 14.8)–(− 21)]; p 0.011). Right ventricular free wall strain (RV-FWS) was lesser in the patient group compared to the control group (− 16 [(− 12.7)–(− 19)] vs − 21.6 [(− 17)–(− 25.3)]; p < 0.001). We found subclinical right ventricular dysfunction in the echocardiographies of COVID-19 patients although there were no risk factors.

show abstract

Section: Discussioncontrasting

confidence: 91%

The effect of moderate and severe COVID-19 pneumonia on short-term right ventricular functions: a prospective observational single pandemic center analysis

Günay

Demiröz

Kahyaoğlu

et al. 2021

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

show abstract

“…Li et al found that RV-LS at − 23% cutoff was associated with AUC 0.87, sensitivity of 94.4%, and specificity of 64.7% [8]. Croft et al reported that LV-GLS reduction of > 8.5 showed trend towards increased mortality, but was not independently associated; the unadjusted or adjusted ratio and their corresponding p values were not thoroughly reported [6].…”

Section: Discussionmentioning

confidence: 99%

“…Three full-text articles were excluded because (1) comparison was between cardiac vs non-cardiac injury (n = 1); (2) comparison was between COVID-19 (+) vs COVID-19 (-) (n = 1); and (3) case series with inadequate comparison (n = 1). There were seven studies comprising of 612 patients in the qualitative and quantitative synthesis [4,[6][7][8][15][16][17]. The baseline characteristics of the included studies are displayed in Table 1.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

Background This systematic review and meta-analysis aimed to assess whether ventricular longitudinal strain can be used as a prognostication tool in patients with coronavirus disease 2019 (COVID-19). Methods Systematic literature searches of PubMed, Embase, and EuropePMC databases were performed on 16 November 2020. Left ventricular global longitudinal strain (LV-GLS) refers to LV contraction measurement using the speckle tracking-based method refers to the mean of strain values of the RV free wall (three segments) measured using echocardiography. The main outcome was poor outcome, defined as a composite of mortality and severe COVID-19. Results Seven studies comprising of 612 patients were included in meta-analysis. Six studies have mortality as their outcome, and 1 study has severity as their outcome. Patients with poor outcome have lower LV-GLS (SMD 1.15 (0.57, 1.72), p < 0.001; I2 70.4%). Each 1% decrease in LV-GLS was associated with 1.4x increased risk of poor outcome (OR 1.37 (1.12, 1.67), p = 0.002; I2 48.8%). Patients with poor outcome have lower RV-LS (SMD 1.18 (0.91, 1.45), p < 0.001; I2 0%). Each 1% decrease in RV-LS was associated with 1.3x increased risk of poor outcome (OR 1.25 (1.15, 1.35), p < 0.001; I2 11.8%). Subgroup analysis showed that for every 1% decrease in LV-GLS and RV-LS is increased mortality with OR of 1.30 (1.12, 1.50) and OR of 1.24 (1.14, 1.35), respectively. Conclusion This study shows that lower LV-GLS and RV-LS measurements were associated with poor outcome in patients with COVID-19. Trial registration PROSPERO CRD42020221144

show abstract

“…In COVID-19 patients, a limited number of echocardiographic evaluations have been done with speckle tracking [ 7 – 9 ]. These evaluations have reported a frequent decrease in right and left ventricular GLS, but they did not provide any comparison with classic indices of systolic function.…”

mentioning

confidence: 99%

Could strain echocardiography help to assess systolic function in critically ill COVID-19 patients?

Gonzalez

Bacariza

Michard

2021

J Clin Monit Comput

View full text Add to dashboard Cite

Strain echocardiography enables the automatic quantification of the global longitudinal strain (GLS), which is a direct measure of ventricular shortening during systole. In the current context of overwhelmed ICUs and clinician shortage, GLS has the advantage to be quick and easy to measure by non-experts. However, little is known regarding its value to assess bi-ventricular systolic function in critically ill COVID-19 patients. Therefore, we designed a study to compare right and left ventricular GLS with classic echo-Doppler indices of systolic function, namely the ejection fraction for the left ventricle (LVEF) and the fractional area change (FAC), the tricuspid annular plane systolic excursion (TAPSE), and the tissue Doppler velocity of the basal free lateral wall (S’) for the right ventricle. Eighty transthoracic echocardiographic evaluations done in 30 ICU patients with COVID-19 were analyzed. We observed a fair relationship (r = 0.73, p < 0.01) between LVEF and left ventricular GLS. The GLS cut-off value of − 22% identified a LVEF < 50% with a sensitivity of 63% and a specificity of 80%. All patients with a GLS > − 17% had a LVEF < 50%. Although statistically significant, relationships between FAC (r = 0.41, p < 0.01), TAPSE (r = 0.26, p < 0.05) and right ventricular GLS were weak. S’ was not correlated with right ventricular GLS. In conclusion, left ventricular GLS was useful to assess left ventricular systolic function. However, right ventricular GLS was poorly correlated with FAC, TAPSE and S’. Further studies are needed to clarify what is the best method to assess right ventricular systolic function in ICU patients with COVID-19.

show abstract

Abnormal Left Ventricular Global Longitudinal Strain By Speckle Tracking Echocardiography in COVID-19 Patients

Cited by 40 publications

References 23 publications

The effect of moderate and severe COVID-19 pneumonia on short-term right ventricular functions: a prospective observational single pandemic center analysis

The effect of moderate and severe COVID-19 pneumonia on short-term right ventricular functions: a prospective observational single pandemic center analysis

Left and right ventricular longitudinal strains are associated with poor outcome in COVID-19: a systematic review and meta-analysis

Could strain echocardiography help to assess systolic function in critically ill COVID-19 patients?

Contact Info

Product

Resources

About