J. Neurosci. Res. volume 86, issue 14, P3126-3139 2008 DOI: 10.1002/jnr.21750 View full text
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Jung-Yu C. Hsu, Stuart A. Stein, Xiao-Ming Xu

Abstract: Thyroid hormone deficiency may cause severe neurological disorders resulting from developmental deficits of the central nervous system. The mutant hyt/hyt mouse, characterized by fetal-onset, life-long hypothyroidism resulting from a point mutation of the thyroid-stimulating hormone receptor of the thyroid gland, displays a variety of abnormalities in motor behavior that are likely associated with dysfunctions of specific brain regions and a defective corticospinal tract (CST). To test the hypothesis that feta…

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