Abnormal gastroesophageal flap valve is highly associated with gastroesophageal reflux disease among subjects undergoing routine endoscopy in Taiwan

Lin, Bor‐Ru; Wong, Jau‐Min; Chang, Ming‐Ling; Liao, Chien-Chung; Yang, Pei‐Ling; Jeng, Jiiang‐Huei; Liao, Wan-Ru; Wang, Teh‐Hong

doi:10.1111/j.1440-1746.2005.04003.x

Cited by 22 publications

(22 citation statements)

References 29 publications

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“…Although the presence of intestinal metaplasia was not assessed in ESEM, the presence of ESEM is a necessary condition for the development of Barrett's esophagus. These findings are consistent with previous reports showing that an abnormal GEFV is associated with reflux esophagitis and Barrett's esophagus 11,25–27 …”

Section: Discussionsupporting

confidence: 94%

Endoscopic grading of gastroesophageal flap valve and atrophic gastritis is helpful to predict gastroesophageal reflux

Kim¹,

Song²,

Kim³

et al. 2007

J of Gastro and Hepatol

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Section: Discussionsupporting

confidence: 94%

Endoscopic grading of gastroesophageal flap valve and atrophic gastritis is helpful to predict gastroesophageal reflux

Kim¹,

Song²,

Kim³

et al. 2007

J of Gastro and Hepatol

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“…Prior studies in adults have also demonstrated similar findings [16], [25], [26]. The present study is the first report to confirm the relationship between altered GEFV grading and prevalence of erosive esophagitis in children.…”

Section: Discussionsupporting

confidence: 88%

Impacts of Endoscopic Gastroesophageal Flap Valve Grading on Pediatric Gastroesophageal Reflux Disease

Chang

Wu²,

Hsu³

et al. 2014

PLoS ONE

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BackgroundGastroesophageal flap valve (GEFV) endoscopic grading is reported to be associated with gastroesophageal reflux disease (GERD) in adults; however its role in pediatric groups remains unknown. This study aimed to investigate the significance of GEFV grading and the associations to multichannel intraluminal impedance and pH monitoring (MII-pH) in children with GERD.MethodsA total of 48 children with GERD symptoms who received esophagogastroduodenoscopy and MII-pH monitoring were enrolled. The degree of GEFV was graded from I to IV according to the Hill classification, and classified into two groups: normal GEFV (Hill grades I and II), and abnormal GEFV (Hill grades III and VI). Endoscopic findings and MII-pH monitoring were analyzed among the groups.ResultsThirty-six patients had normal GEFV while 12 had abnormal GEFV. The presence of erosive esophagitis was significantly more common in the patients with abnormal GEFV (p = 0.037, OR 9.84, 95% CI 1.15–84.42). Pathological acidic gastroesophageal reflux (GER) determined by MII-pH was more prevalent in the patients with loosened GEFV geometry (p = 0.01, OR 7.0, 95% CI 1.67–27.38). There were significant positive correlations between GEFV Hill grading I to IV and the severity of erosive esophagitis (r = 0.49, p<0.001), percentage of supine acid reflux (r = 0.37, p = 0.009), percentage of total acid reflux (r = 0.3284, p = 0.023), and DeMeester score (r = 0.36, p = 0.01) detected by pH monitoring. In the impedance study, GEFV Hill grading also positively correlated to median number of acid reflux events (r = 0.3015, p = 0.037).ConclusionsGEFV dysfunction highly associated with acid GER and severe erosive esophagitis. An abnormal GEFV is a sign of acid GER in children.

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“…Moreover, the length of the hernia seems to affect the severity of GERD [19]. [21,22]. Interestingly, Takeuchi et al found that GEFV grade could predict the appearance of a newly developing esophagitis after Helicobacter pylori eradication [23].…”

Section: Discussionmentioning

confidence: 97%

The Effect of Gastroesophageal Flap Valve Appearance on the Management of Patients with Symptoms of Gastroesophageal Reflux Disease

Xirouchakis¹,

Kamberoglou²,

Kalos³

et al. 2008

Dig Dis Sci

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Abnormal gastroesophageal flap valve is highly associated with gastroesophageal reflux disease among subjects undergoing routine endoscopy in Taiwan

Abstract: Taiwanese patients with abnormal GEFVs share similar characteristics and risk factors with the patients who have EE. Endoscopic grading of the GEFV is highly associated with GERD, and in particular EE, in subjects undergoing routine endoscopy.

Cited by 22 publications

References 29 publications

Endoscopic grading of gastroesophageal flap valve and atrophic gastritis is helpful to predict gastroesophageal reflux

Endoscopic grading of gastroesophageal flap valve and atrophic gastritis is helpful to predict gastroesophageal reflux

Impacts of Endoscopic Gastroesophageal Flap Valve Grading on Pediatric Gastroesophageal Reflux Disease

The Effect of Gastroesophageal Flap Valve Appearance on the Management of Patients with Symptoms of Gastroesophageal Reflux Disease

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