Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging

Adleman, Nancy E.; Kayser, Reilly; Olsavsky, Aviva K.; Bones, Brian L.; Muhrer, Eli; Fromm, Stephen J.; Pine, Daniel S.; Zarate, Carlos A.; Leibenluft, Ellen; Brotman, Melissa A.

doi:10.1016/j.pscychresns.2013.01.006

Cited by 24 publications

(23 citation statements)

References 16 publications

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“…Further, the reduced corpus callosum volume and white matter integrity aligns with twin studies suggesting genetically influenced alterations of this structure in BP 88,89 . Gray matter reduction in temporal structures, including the superior temporal sulcus (STS) and the lingual and fusiform gyri, are noteworthy given the involvement of these structures in facial emotion identification, a process impaired in BP individuals and adolescents at high-risk 90–94 .…”

Section: Discussionmentioning

confidence: 99%

Multisystem Component Phenotypes of Bipolar Disorder for Genetic Investigations of Extended Pedigrees

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Multisystem Component Phenotypes of Bipolar Disorder for Genetic Investigations of Extended Pedigrees

et al. 2014

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“…The first-level literature search yielded 1,181 unique published articles with 155 meeting initial inclusion criteria, including 3 four-group studies with separate BD-youth and BD-adult participant groups 16,17,19 (Figure 1). …”

Section: Methodsmentioning

confidence: 99%

“…To our knowledge, only four currently-published task-related functional magnetic resonance imaging (fMRI) studies have directly compared BD-youths and BD-adults in the same study 16–19 . Specifically, Kim (2012) found that BD-youths had greater amygdala activation during emotional face recognition than BD-adults 16 .…”

Section: Introductionmentioning

confidence: 99%

“…Weathers (2012) found decreased anterior cingulate cortex (ACC) activation in BD-youths during failed response inhibition 17 , while Weathers (2013) found increased prefrontal cortex (PFC) activation during successful response switches 18 . Adelman (2013) found decreased fusiform activation in both BD-youths and BD-adults during successful emotional face encoding 19 . More such studies are needed to elucidate developmentally-unique brain alterations among BD-youths versus BD-adults, but multi-group and longitudinal fMRI studies are inherently costly and the latter require time to image BD-youths as they age, a process that can not be expedited.…”

Section: Introductionmentioning

confidence: 99%

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Developmental Meta-analyses of the Functional Neural Correlates of Bipolar Disorder

et al. 2014

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“…Neuroimaging studies can help elucidate such processes by identifying abnormal functioning in neural circuitries supporting information processing domains known to be aberrant in individuals with established bipolar disorder, such as face emotion processing. For example, youth and adults with bipolar disorder are impaired in both memory for emotional faces (Dickstein et al, 2007;Adleman et al, 2013) and identification of facial emotional expressions (Rich et al, 2006;Guyer et al, 2007). Comparing BO and NBO in neuroimaging studies of face emotion processing circuitry may thus help identify biomarkers reflecting risk for, or protection against, bipolar disorder specifically.…”

Section: Introductionmentioning

confidence: 99%

Altered amygdala-prefrontal response to facial emotion in offspring of parents with bipolar disorder

Manelis

Ladouceur

Graur

et al. 2015

Brain

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This study aimed to identify neuroimaging measures associated with risk for, or protection against, bipolar disorder by comparing youth offspring of parents with bipolar disorder versus youth offspring of non-bipolar parents versus offspring of healthy parents in (i) the magnitude of activation within emotional face processing circuitry; and (ii) functional connectivity between this circuitry and frontal emotion regulation regions. The study was conducted at the University of Pittsburgh Medical Centre. Participants included 29 offspring of parents with bipolar disorder (mean age = 13.8 years; 14 females), 29 offspring of non-bipolar parents (mean age = 13.8 years; 12 females) and 23 healthy controls (mean age = 13.7 years; 11 females). Participants were scanned during implicit processing of emerging happy, sad, fearful and angry faces and shapes. The activation analyses revealed greater right amygdala activation to emotional faces versus shapes in offspring of parents with bipolar disorder and offspring of non-bipolar parents than healthy controls. Given that abnormally increased amygdala activation during emotion processing characterized offspring of both patient groups, and that abnormally increased amygdala activation has often been reported in individuals with already developed bipolar disorder and those with major depressive disorder, these neuroimaging findings may represent markers of increased risk for affective disorders in general. The analysis of psychophysiological interaction revealed that offspring of parents with bipolar disorder showed significantly more negative right amygdala-anterior cingulate cortex functional connectivity to emotional faces versus shapes, but significantly more positive right amygdala-left ventrolateral prefrontal cortex functional connectivity to happy faces (all P-values corrected for multiple tests) than offspring of non-bipolar parents and healthy controls. Taken together with findings of increased amygdala-ventrolateral prefrontal cortex functional connectivity, and decreased amygdala-anterior cingulate cortex functional connectivity previously shown in individuals with bipolar disorder, these connectivity patterns in offspring of parents with bipolar disorder may be risk markers for, rather than markers conferring protection against, bipolar disorder in youth. The patterns of activation and functional connectivity remained unchanged after removing medicated participants and those with current psychopathology from analyses. This is the first study to demonstrate that abnormal functional connectivity patterns within face emotion processing circuitry distinguish offspring of parents with bipolar disorder from those of non-bipolar parents and healthy controls.

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Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging

Cited by 24 publications

References 16 publications

Multisystem Component Phenotypes of Bipolar Disorder for Genetic Investigations of Extended Pedigrees

Multisystem Component Phenotypes of Bipolar Disorder for Genetic Investigations of Extended Pedigrees

Developmental Meta-analyses of the Functional Neural Correlates of Bipolar Disorder

Altered amygdala-prefrontal response to facial emotion in offspring of parents with bipolar disorder

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