Abnormal Functional Connectivity of Anterior Cingulate Cortex in Patients With Primary Insomnia: A Resting-State Functional Magnetic Resonance Imaging Study

Yan, Chao-Qun; Liu, Cun‐Zhi; Wang, Xu; Huo, Jian-Wei; Zhou, Ping; Zhang, Shuai; Fu, Qing-Nan; Zhang, Jie; Wang, Zhongyan; Liu, Qingquan

doi:10.3389/fnagi.2018.00167

Cited by 29 publications

(36 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship between slow-wave and fast-wave activity is known as the cross-talk between the subcortical and cortical brain regions [46,47]. Increased slow-fast wave coupling is considered to reflect increased attentional control [48] and cortisol levels [49], and many studies using fMRI also found that chronic insomnia patients showed abnormal brain connectivity [50,51]. In this regard, this result may suggest that insomnia patients have higher cognitive activity and greater load on the brain by accepting excessive information from external stimuli.…”

Section: Discussionmentioning

confidence: 99%

Daytime Neurophysiological Hyperarousal in Chronic Insomnia: A Study of qEEG

Park

Choi

2020

JCM

View full text Add to dashboard Cite

Background: The hyperarousal model demonstrates that instability of sleep-wake regulation leads to insomnia symptoms and various neurophysiological hyperarousal states. Previous studies have shown that hyperarousal states that appear in chronic insomnia patients are not limited to sleep at nighttime but are stable characteristics that extend into the daytime. However, this phenomenon is mainly measured at bedtime, so it hard to determine whether it is maintained throughout a 24 h cycle or if it just appears at bedtime. Methods: We examined the resting state qEEG (quantitative electroencephalogram) and ECG (electrocardiogram) of chronic insomnia patients (n = 24) compared to good sleepers (n = 22) during the daytime. Results: As compared with controls, participants with insomnia showed a clearly high beta band activity in eyes closed condition at all brain areas. They showed a low frequency band at the frontal area; high frequency bands at the central and parietal areas were found in eyes open condition. Significantly higher heart rates were also found in the chronic insomnia group. Conclusion: These findings suggest that chronic insomnia patients were in a state of neurophysiological hyperarousal during the middle of the day due to abnormal arousal regulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Daytime Neurophysiological Hyperarousal in Chronic Insomnia: A Study of qEEG

Park

Choi

2020

JCM

View full text Add to dashboard Cite

show abstract

“…It has also been suggested that communication between the left and right hemispheres of the human brain is crucial for cognition and emotion processing (14). The VMHC has also been applied to study Parkinson's disease, schizophrenia, and insomnia (15). Additionally, previous VMHC analyses of stroke have shown that altered VMHC is associated with motor function assessment and illness duration (16).…”

Section: Introductionmentioning

confidence: 99%

Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Yao

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

Background: Stroke with basal ganglia damage (SBG) is a neurological disorder characterized by cognitive impairment. The neurobiological mechanism of cognitive impairment in stroke patients with basal ganglia damage (SBG patients) remains unclear. This study aimed to explore the underlying neurobiological mechanism of cognitive impairment in SBG patients using resting-state functional magnetic resonance imaging (rs-fMRI). Methods: The differences in functional connectivity (FC) between 14 SBG patients (average age: 61.00 ± 7.45 years) and 21 healthy controls (HC) (average age: 60.67 ± 6.95 years) were examined using voxel-mirrored homotopic connectivity (VMHC) and degree centrality (DC). Moreover, we compared the cognitive functions of SBG patients with HC using the Chinese Revised Wechsler Adult Intelligence Scale (WAIS-RC) and Wechsler Memory Scale (WMS). Results: Full-scale intelligence quotient (FIQ) (t = 2.810, p < 0.010) and memory quotient (MQ) (t = 2.920, p < 0.010) scores of SBG patients were significantly lower than those of HC. Compared with HC, significantly decreased VMHC values in the bilateral angular gyrus, supramarginal gyrus, inferior frontal gyrus, middle temporal gyrus, hippocampus, precuneus, precentral gyrus, and middle occipital gyrus and decreased DC values in the right supramarginal gyrus, bilateral angular gyrus, and right postcentral gyrus were observed in SBG patients. Moreover, the VMHC values in the angular gyrus, inferior frontal gyrus, supramarginal gyrus, and middle temporal gyrus and the DC values in the right supramarginal gyrus were significantly correlated with cognitive functions in all participants. Conclusion: Our findings may provide a neural basis for cognitive impairments in SBG patients. Furthermore, local abnormalities of functional networks and interhemispheric interaction deficits may provide new ideas and insights for understanding and treating SBG patients' cognitive impairments.

show abstract

“…Baseline characteristics have previously been described in detail ( 41 ). A total of 26 PI patients and 28 healthy controls were enrolled.…”

Section: Resultsmentioning

confidence: 99%

Abnormal Global Brain Functional Connectivity in Primary Insomnia Patients: A Resting-State Functional MRI Study

et al. 2018

Self Cite

View full text Add to dashboard Cite

Background: Resting-state functional magnetic resonance imaging (fMRI) studies have uncovered the disruptions of functional brain networks in primary insomnia (PI) patients. However, the etiology and pathogenesis underlying this disorder remains ambiguous, and the insomnia related symptoms are influenced by a complex network organization in the brain. The purpose of this study was to explore the abnormal intrinsic functional hubs in PI patients using a voxel-wise degree centrality (DC) analysis and seed-based functional connectivity (FC) approach.Methods: A total of 26 PI patients and 28 healthy controls were enrolled, and they underwent resting-state fMRI. Degree centrality was measured across the whole brain, and group differences in DC were compared. The peak points, which significantly altered DC between the two groups, were defined as the seed regions and were further used to calculate FC of the whole brain. Later, correlation analyses were performed between the changes in brain function and clinical features.Results: Primary insomnia patients showed DC values lower than healthy controls in the left inferior frontal gyrus (IFG) and middle temporal gyrus (MTG) and showed a higher DC value in the right precuneus. The seed-based analyses demonstrated decreased FC between the left MTG and the left posterior cingulate cortex (PCC), and decreased FC was observed between the right precuneus and the right lateral occipital cortex. Reduced DC in the left IFG and decreased FC in the left PCC were positively correlated with the Pittsburgh sleep quality index and the insomnia severity index.Conclusions: This study revealed that PI patients exhibited abnormal intrinsic functional hubs in the left IFG, MTG, and the right precuneus, as well as abnormal seed-based FC in these hubs. These results contribute to better understanding of how brain function influences the symptoms of PI.

show abstract

Abnormal Functional Connectivity of Anterior Cingulate Cortex in Patients With Primary Insomnia: A Resting-State Functional Magnetic Resonance Imaging Study

Cited by 29 publications

References 51 publications

Daytime Neurophysiological Hyperarousal in Chronic Insomnia: A Study of qEEG

Daytime Neurophysiological Hyperarousal in Chronic Insomnia: A Study of qEEG

Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Abnormal Global Brain Functional Connectivity in Primary Insomnia Patients: A Resting-State Functional MRI Study

Contact Info

Product

Resources

About