Abnormal function of CD4+ helper/inducer T lymphocytes in a patient with widespread human papillomavirus type 3-related infection

CD4+ T lymphocytopenia with disseminated HPV

“…Most reports have not included HPV typing. Of those that do, one reported HPV 3, 6 one reported multiple HPV types: 3 and 49 from the hand warts and type 6 from the anogenital warts, 12 and Requena et al 13 . reported HPV 2, similar to our case.…”

“…There have been nine previous reports of human papillomavirus infection in association with idiopathic T‐cell lymphocytopenia 6–13 . Most reports have not included HPV typing.…”

Idiopathic CD4+ T Lymphocytopenia Associated with Disseminated Flat Warts and Alopecia Areata

“…Since the Centers for Disease Control and Prevention (CDC) formal definition of ICL in 1992, four patients with ICL and extensive and resistant flat warts have been reported in whom the presence of HPV DNA has been investigated by PCR analysis. HPV type 3 has been identified in two previous patients (2, 4) and in the case presented here. In one patient, both HPV types 3 and 49 DNA has been reported (5).…”

“…ICL frequently manifests with cutaneous diseases, which may be the only presenting symptoms. Infectious diseases are the most common manifestations and include viral (herpes viruses, molluscum contagiosum, papilloma virus), fungal and bacterial infections (2–6). Since the Centers for Disease Control and Prevention (CDC) formal definition of ICL in 1992, four patients with ICL and extensive and resistant flat warts have been reported in whom the presence of HPV DNA has been investigated by PCR analysis.…”

Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia

“…phytohaemagglutinin), decreased CD4/CD8 lymphocyte ratio, and/or an expansion of large granular CD8+ lymphocytes are common to immunocompromised patients with EV‐like eruptions 39–55 . Idiopathic CD4 lymphopenia (persistent CD4 counts < 300 mm −3 and/or < 20% of the total T cells in the absence of HIV 1/2 or HTLV 1/2 infection 56 ) has been associated with extragenital HPV 18‐positive bowenoid papulosis 57 and verrucosis, 58–61 but not EV‐like eruptions.…”