Abnormal frontal cortex white matter connections in bipolar disorder: A DTI tractography study

Lin, Fuchun Joseph; Weng, Shenhong; Xie, Baojun; Wu, Guangyao; Lei, Hao

doi:10.1016/j.jad.2010.12.018

Cited by 106 publications

(84 citation statements)

References 53 publications

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“…Interestingly, BD patients exhibit microstructural changes within the uncinate fasciculus, which links the temporal lobe with the IFG (68)(69)(70). There is also replicated evidence in BD for volumetric decreases within GM connections of the IFG, including the amygdala (7), the hippocampus (71), and the anterior cingulate (6).…”

Section: Discussionmentioning

confidence: 99%

Brain Structural Signature of Familial Predisposition for Bipolar Disorder: Replicable Evidence For Involvement of the Right Inferior Frontal Gyrus

Hájek

Cullis

Novák

et al. 2013

Biological Psychiatry

123

110

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Section: Discussionmentioning

confidence: 99%

Brain Structural Signature of Familial Predisposition for Bipolar Disorder: Replicable Evidence For Involvement of the Right Inferior Frontal Gyrus

Hájek

Cullis

Novák

et al. 2013

Biological Psychiatry

123

110

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show abstract

“…Diffusion along the two orthogonal directions perpendicular to the main diffusion direction is called radial diffusivity (RD) and expressed as the average of the second and third eigenvalues [RD=(ʎ 2 +ʎ 3 )/2]. DTI has been shown to be sensitive in detecting subtle (but functionally significant) ultrastructural abnormalities in WM (in cerebral small vessel disease but also, multiple sclerosis, bipolar disorder, and schizotypal personality disorder [20][21][22][23] ).…”

mentioning

confidence: 99%

Randomized Clinical Trial of Dialysate Cooling and Effects on Brain White Matter

Eldehni

Odudu

McIntyre

2015

Journal of the American Society of Nephrology

196

188

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Hemodialysis is associated with significant circulatory stress that could produce recurrent and cumulative ischemic insults to multiple organs, such as the brain. We aimed to characterize hemodialysis-induced brain injury by longitudinally studying the effects of hemodialysis on brain white matter microstructure and further examine if the use of cooled dialysate could provide protection against hemodialysis-associated brain injury. In total, 73 patients on incident hemodialysis starting within 6 months were randomized to dialyze with a dialysate temperature of either 37°C or 0.5°C below the core body temperature and followed up for 1 year. Brain white matter microstructure was studied by diffusion tensor magnetic resonance imaging at baseline and follow-up (38 patients available for paired analysis). Intradialytic hemodynamic stress was quantified using the extrema points analysis model. Patients on hemodialysis exhibited a pattern of ischemic brain injury (increased fractional anisotropy and reduced radial diffusivity). Cooled dialysate improved hemodynamic tolerability, and changes in brain white matter were associated with hemodynamic instability (higher mean arterial pressure extrema points frequencies were associated with higher fractional anisotropy [peak r=0.443, P,0.03] and lower radial diffusivity [peak r=20.439, P,0.02]). Patients who dialyzed at 0.5°C below core body temperature exhibited complete protection against white matter changes at 1 year. Our data suggest that hemodialysis results in significant brain injury and that improvement in hemodynamic tolerability achieved by using cooled dialysate is effective at abrogating these effects. This intervention can be delivered without additional cost and is universally applicable.

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“…In line, reduced white matter integrity in the anterior limb of the internal capsule has also been repeatedly observed in bipolar patients [173,185,186]. Similar, reduced integrity of the uncinate fasciculus, which interconnects the amygdala with the orbitofrontal cortex and the anterior cingulate cortex [187], has also been frequently observed in depressed and euthymic bipolar disorder patients [173,180,182,183,188,189]. Although, increased white matter integrity and increased number of fibers have also been reported for the uncinate fasciculus [180,190].…”

Section: White Matter Alterationsmentioning

confidence: 62%

“…Interestingly, a normalizing effect of lithium on the volume of the corpus callosum has been observed [178], and a study of euthymic bipolar disorder patients even reported increased integrity of the corpus callosum [179]. Furthermore, all but one [180] tractography study showed reduced white matter integrity in the anterior thalamic radiation [181][182][183], which passes through the anterior limb of the internal capsule [184] in depressed, euthymic, and manic patients. In line, reduced white matter integrity in the anterior limb of the internal capsule has also been repeatedly observed in bipolar patients [173,185,186].…”

Section: White Matter Alterationsmentioning

confidence: 99%

Emotional and Motivational Processes in Bipolar Disorder: A Neural Network Perspective

Wessa¹,

Linke²

2013

Psychiatric Disorders - New Frontiers in Affective Disorders

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Abnormal frontal cortex white matter connections in bipolar disorder: A DTI tractography study

Cited by 106 publications

References 53 publications

Brain Structural Signature of Familial Predisposition for Bipolar Disorder: Replicable Evidence For Involvement of the Right Inferior Frontal Gyrus

Brain Structural Signature of Familial Predisposition for Bipolar Disorder: Replicable Evidence For Involvement of the Right Inferior Frontal Gyrus

Randomized Clinical Trial of Dialysate Cooling and Effects on Brain White Matter

Emotional and Motivational Processes in Bipolar Disorder: A Neural Network Perspective

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