1990
DOI: 10.1001/archotol.1990.01870100061013
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Abnormal Differentiation of Human Papillomavirus-Induced Laryngeal Papillomas

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Cited by 44 publications

(28 citation statements)
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“…Papilloma cells proliferate more slowly than normal laryngeal epithelial cells (26), in accord with the elevated level of p21 CIP1/WAF1 reported here. Overexpression of p21…”
supporting
confidence: 89%
“…Papilloma cells proliferate more slowly than normal laryngeal epithelial cells (26), in accord with the elevated level of p21 CIP1/WAF1 reported here. Overexpression of p21 CIP1/WAF1 could also lead to disruption of normal epithelial differentiation programming previously observed in papilloma tissue (26,29).…”
supporting
confidence: 89%
“…Papilloma cells proliferate more slowly than normal laryngeal epithelial cells (26), in accord with the elevated level of p21 CIP1/WAF1 reported here. Overexpression of p21 CIP1/WAF1 could also lead to disruption of normal epithelial differentiation programming previously observed in papilloma tissue (26,29). This hypothesis is supported by the finding that expression of p21 CIP1/WAF1 in keratinocytes inhibits expression of differentiation markers such as keratin 1, involucrin, and filaggrin (9).…”
supporting
confidence: 89%
See 2 more Smart Citations
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Papilloma cells proliferate more slowly than normal laryngeal epithelial cells (26), in accord with the elevated level of p21 CIP1/WAF1 reported here. Overexpression of p21…”
supporting
confidence: 89%
“…Papilloma cells proliferate more slowly than normal laryngeal epithelial cells (26), in accord with the elevated level of p21 CIP1/WAF1 reported here. Overexpression of p21 CIP1/WAF1 could also lead to disruption of normal epithelial differentiation programming previously observed in papilloma tissue (26,29).…”
supporting
confidence: 89%
“…Papilloma cells proliferate more slowly than normal laryngeal epithelial cells (26), in accord with the elevated level of p21 CIP1/WAF1 reported here. Overexpression of p21 CIP1/WAF1 could also lead to disruption of normal epithelial differentiation programming previously observed in papilloma tissue (26,29). This hypothesis is supported by the finding that expression of p21 CIP1/WAF1 in keratinocytes inhibits expression of differentiation markers such as keratin 1, involucrin, and filaggrin (9).…”
supporting
confidence: 89%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Lin et al (34) reported that COX-2 expression and/or PGE 2 activated PI3K, and PI3K inhibition reduced COX-2 levels. Thus, activation of PI3K via PGE 2 receptors, in addition to the EGFR, might play a role in the proposed feedback loop in our cells. COX-2 -derived prostaglandins have been reported to increase cell proliferation and Research.…”
Section: Discussionmentioning
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Of note, 60% of 2D RRP cell culture studies were follow‐ups within the same research group (Table I). The model developed by Steinberg et al in 1982 49 was used in 19 follow‐up studies 59,62–79 . 2D models developed by Yuan et al in 2012 55 and Bedard et al in 2021 56 were each used in one follow‐up study 61,80 .…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.