Abnormal baseline brain activity in posttraumatic stress disorder: A resting-state functional magnetic resonance imaging study

Yin, You; Li, Lingjiang; Jin, Changfeng; Hu, Xiaolei; Duan, Lian; Eyler, Lisa T.; Gong, Qiyong; Song, Ming; Jiang, Tianzi; Liao, Mei; Zhang, Yan; Li, Weihui

doi:10.1016/j.neulet.2011.02.069

Cited by 101 publications

(75 citation statements)

References 41 publications

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“…The decreased spontaneous IC brain activity observed in the current study is consistent with an independent Rs-fMRI study investigating a different cohort of PTSD patients that experienced the same earthquake [51]. In this previous study, subjects were recruited from 9 to 15 months post-earthquake and presented with relative acute PTSD.…”

Section: Discussionsupporting

confidence: 90%

Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Zhu¹,

Zhang²,

Zhan³

et al. 2014

Comprehensive Psychiatry

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Section: Discussionsupporting

confidence: 90%

Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Zhu¹,

Zhang²,

Zhan³

et al. 2014

Comprehensive Psychiatry

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“…Few studies have explored resting-state activity of this network. With a large sample size, a restingstate fMRI study based on low frequency amplitude index indicated that the right MFG in the patients with earthquake-related PTSD had significantly increased activity as compared with the TEC group [40]. Contradictory to observations from resting-state studies, results of this task-based study indicated decreased MFG activation or functional connectivity in the PTSD patients.…”

Section: Discussionmentioning

confidence: 48%

Typhoon-Related Post-Traumatic Stress Disorder and Trauma Might Lead to Functional Integration Abnormalities in Intra- and Inter-Resting State Networks: a Resting-State Fmri Independent Component Analysis

Zhang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Functional connectivity studies based on region of interest approach suggest altered functional connectivity of the default mode network (DMN), executive control network (ECN), and salience network (SN). The aim of this study is to determine whether intranetwork and internetwork brain connectivity are altered in both post-traumatic stress disorder (PTSD) patients and traumatized subjects without PTSD using a data-driven approach. Methods: Resting-state functional MRI data were acquired for 27 patients with typhoon-related PTSD, 33 trauma-exposed controls (TEC), and 30 healthy controls (HC). Functional connectivity within the DMN, ECN, and SN as well as functional and effective connectivity between these resting-state networks were examined with independent component analysis (ICA), and then compared between groups by conducting analysis of variance. Results: Within the DMN, the TEC group showed decreased and increased functional connectivity in the superior frontal gyrus compared with the PTSD group and the HC group, respectively. The TEC group showed increased angular functional connectivity within the DMN and decreased functional connectivity in the superior temporal gyrus/posterior insula within the SN relative to the HC group. Compared with the TEC group, the PTSD group showed increased functional connectivity in the middle frontal gyrus and supplementary motor area within the ECN as well as in the inferior frontal gyrus/anterior insula within the SN. The PTSD group showed decreased functional connectivity in the supplementary motor area within the SN relative to both control groups. Moreover, the PTSD showed increased excitatory influence from the ECN to DMN compared with both control groups, while the TEC group showed increased inhibitory influence from the DMN to ECN compared with the HC group. Intranetwork functional connectivity within the DMN and SN is altered in traumatized subjects irrespective of PTSD diagnosis. PTSD patients also showed altered intranetwork functional connectivity within the ECN. Conclusions: Distinct changes of effective connectivity between the DMN and ECN in the PTSD group and TEC group may reflect different compensatory mechanisms for rebalance of resting-state networks in the two groups.

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“…This suggests an increased functional coupling within those regions. 42 Linear regression of cortical thickness and medial PFC ALFF revealed a positive correlation with PTSD symptoms. 32 Indeed, Bing et al 32 concluded that structural integrity of the medial PFC, which may influence its functional connectivity with other networks, may contribute to PTSD progression.…”

Section: Posttraumatic Stress Disordermentioning

confidence: 94%

Resting-State Neuroimaging Studies: A New Way of Identifying Differences and Similarities among the Anxiety Disorders?

et al. 2014

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This review examines recent functional neuroimaging research of resting-state regional connectivity between brain regions in anxiety disorders. Studies compiled in the PubMedNational Center for Biotechnology Information database targeting resting-state functional connectivity in anxiety disorders were reviewed. Diagnoses included posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), panic disorder (PD), and specific phobia (SP).Alterations to network connectivity were demonstrated in PTSD, GAD, SAD, OCD, and PD in several resting-state investigations. Differences from control subjects were primarily observed in the default mode network within PTSD, SAD, and OCD. Alterations within the salience network were observed primarily in PTSD, GAD, and SAD. Alterations in corticostriatal networks were uniquely observed in OCD. Finally, alterations within somatosensory networks were observed in SAD and PD investigations. Resting-state studies involving SPs as a primary diagnosis (with or without comorbidities) were not generated during the literature search. The emerging use of resting-state paradigms may be an effective method for understanding associations between anxiety disorders. Targeted studies of PD and SPs, meta-analyses of the studies conducted to date, and studies of the impact of specific comorbid presentations, are recommended future research directions. W W W Études de neuroimagerie à l'état de repos : une nouvelle façon d'identifier les différences et les similitudes des troubles anxieux?Cette revue examine la recherche récente en neuroimagerie fonctionnelle sur la connectivité régionale à l'état de repos entre les régions du cerveau dans les troubles anxieux. Des études de la base de données PubMed-National Center for Biotechnology Information portant sur la connectivité fonctionnelle à l'état de repos dans les troubles anxieux ont été examinées. Les diagnostics incluaient notamment le trouble de stress post-traumatique (TSPT), le trouble d'anxiété généralisée (TAG), le trouble d'anxiété sociale (TAS), le trouble obsessionnel-compulsif (TOC), le trouble panique (TP), et la phobie spécifique (PS). Les modifications de la connectivité du réseau ont été démontrées dans les TSPT, TAG, TAS, TOC et TP dans plusieurs investigations à l'état de repos. Les différences par rapport aux sujets témoins ont été surtout observées dans le réseau du mode par défaut dans le TSPT, le TAS, et le TOC. Les modifications du réseau de saillie ont été surtout observées dans le TSPT, le TAG, et le TAS. Les modifications des réseaux corticostriataux ont été observées seulement dans le TOC. Enfin, les modifications des réseaux somatosensoriels ont été observées dans les investigations du TAS et du TP. Les études à l'état de repos impliquant les PS comme diagnostic primaire (avec ou sans comorbidités) n'ont pas été générées durant la recherche de la littérature. L'utilisation naissante des paradigmes de l'état au repos peut se révéler une méthode ef...

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Abnormal baseline brain activity in posttraumatic stress disorder: A resting-state functional magnetic resonance imaging study

Cited by 101 publications

References 41 publications

Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Typhoon-Related Post-Traumatic Stress Disorder and Trauma Might Lead to Functional Integration Abnormalities in Intra- and Inter-Resting State Networks: a Resting-State Fmri Independent Component Analysis

Resting-State Neuroimaging Studies: A New Way of Identifying Differences and Similarities among the Anxiety Disorders?

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