2007
DOI: 10.1001/archpsyc.64.1.97
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Abstract: This is the first evidence in juveniles that generalized anxiety disorder-associated patterns of pathologic fear circuit activation are particularly evident during certain attention states. Specifically, fear circuit hyperactivation occurred in an attention state involving focus on subjectively experienced fear. These findings underscore the importance of attention and its interaction with emotion in shaping the function of the adolescent human fear circuit.

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Cited by 394 publications
(448 citation statements)
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References 50 publications
(67 reference statements)
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“…Taken together, the current results indicate that greater activation in a broad neural network involved in signaling salience, appraising and regulating emotions predicts better response to treatment among anxious youth. Although anxious youths exhibit heightened amygdala reactivity to threat (Killgore and Yurgelun-Todd, 2005;McClure et al, 2007b;Thomas et al, 2001), and one previous study demonstrated that greater amygdala predicted better treatment response in a small sample of anxious youth (McClure et al, 2007a), we did not find evidence that amygdala activation predicted treatment response. Prior studies using data-driven approaches have also failed to find amygdala activation as a significant predictor of response to treatment (Ball et al, 2014a), suggesting that pathophysiology, as reflected by abnormal patterns of brain reactivity, may not necessarily serve as predictors of treatment response.…”
Section: Predictors Of Treatment Response In Anxious Youthcontrasting
confidence: 80%
See 1 more Smart Citation
“…Taken together, the current results indicate that greater activation in a broad neural network involved in signaling salience, appraising and regulating emotions predicts better response to treatment among anxious youth. Although anxious youths exhibit heightened amygdala reactivity to threat (Killgore and Yurgelun-Todd, 2005;McClure et al, 2007b;Thomas et al, 2001), and one previous study demonstrated that greater amygdala predicted better treatment response in a small sample of anxious youth (McClure et al, 2007a), we did not find evidence that amygdala activation predicted treatment response. Prior studies using data-driven approaches have also failed to find amygdala activation as a significant predictor of response to treatment (Ball et al, 2014a), suggesting that pathophysiology, as reflected by abnormal patterns of brain reactivity, may not necessarily serve as predictors of treatment response.…”
Section: Predictors Of Treatment Response In Anxious Youthcontrasting
confidence: 80%
“…Youth who demonstrate greater activation in vlPFC and dlPFC prior to treatment may be more effective in regulation of responses to threatening stimuli and thus able to achieve greater therapeutic gains. In support, greater vlPFC activation has been observed in anxious youth compared with healthy controls during fear processing (McClure et al, 2007b), with some evidence that vlPFC activation is negatively related to anxiety severity (Monk et al, 2006) and increases following treatment for anxiety (Maslowsky et al, 2010), possibly reflecting improvements in emotion regulation. Another possibility, however, is that youth with greater vlPFC and dlPFC activation prior to treatment require increased effort to regulate emotions, which may become more automatic following treatment and contribute to greater improvement in symptoms.…”
Section: Discussionmentioning
confidence: 86%
“…fMRI studies of this region in youth with GAD have revealed increased activation during the viewing of fearful faces (McClure et al 2007) and ACC activation correlates with amygdala and VLPFC activation in youth with GAD. Further, in the present sample, baseline activation of this structure predicted treatment-associated changes in anxiety symptoms.…”
Section: Discussionmentioning
confidence: 99%
“…These two structures were examined given their central role in the pathophysiology of anxiety. In this regard, most fMRI studies of youth with anxiety disorders suggest increased activation of the VLPFC (Monk et al 2006;McClure et al 2007;Guyer et al 2008;Monk et al 2008;Beesdo et al 2009;Strawn et al 2012a) and also suggest structural deficits in this region in children and adolescents with anxiety disorders . The VLPFC subserves a number of regulatory functions, including modulation of amygdala activity (Monk et al 2008) and is responsible for conscious regulation of affect (Phillips et al 2008).…”
Section: Introductionmentioning
confidence: 99%
“…We hypothesized that for GAD responders, both acute and chronic riluzole treatment would be associated with increased hippocampal NAA, and that NAA increases would correspond to reductions in pathological worry and anxiety. In exploratory analyses, we investigated patterns of acute and chronic change in NAA in additional brain regions subserving anxiety and worry, including dorsolateral prefrontal cortex (DLPFC) (29), anterior cingulate cortex (ACC) (30)(31)(32), and prefrontal white matter (33).…”
Section: Introductionmentioning
confidence: 99%