Abietane Acids: Sources, Biological Activities, and Therapeutic Uses

Abstract

Biological Activities and Uses The use of pine resin as a whole or its derivatives, essence, and colophony as expectorants, modifiers of bronchial secretions, and antiseptics for the urinary tract, as weli as rubefacients and vessicants in poultices and creams in veterinary practice is described in several Pharmacognosy and Medicinal Plant treatises (66, 67). In recent years (i967-i992), studies on the biological activities of abietane acids have been performed with pure compounds and activities like antimicrobial, antiulcer, cardiovascular, allergenic, antiallergic, and many uses in cosmetics and dermatologic preparations have been reported for some of them. Antimicrobial Activity The antimicrobial activity of pisiferic acid (48) and its derivatives has been established against Pseudomonas, Proteus, and Klebsiella (68) as have its antibacterial actions against Gram-positive microorganisms, its antifungal activity, and its activity in experimental carcinoma of the uterus (HeLa-S3 cells) (55, 58). In the systems assayed, pisiferic acid (48) was active against Proteus vulgaris, Staphylococcus aureus, Bacillus subtilis, Pyricularia oryzae, and HeLa-S3 celis, while methylation of the

Crystal structure of 13-hydroxy-8(9)-abieten-20-oic acid, C20H32O3

“…The title compound is atypical abietane diterpenoid and shows antimicrobial, antiulcer, and cardiovasculara ctivities [1][2].I n 1995 the crystal structure was analysed, but no crystal data were given in the paper [3].Inorder to further confirm the structure and providecompletecrystal data,werepeated the work.The compound crystallizes with two molecules in the trigonalcrystal system with space group P3 1 2 1 (figure). Geometric parameters of the titlecompoundare in the usual ranges.…”

Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel

“…The trees use resins as a defense and the concentration is known to increase in infected trees, probably since it is toxic both to beetles and fungi (Beath 1912, Norin and Winell 1971, San Feliciano et al 1993, Gonzalez 2015.…”

In Vitro and In Vivo Studies of the Trypanocidal Activity of Four Terpenoid Derivatives against Trypanosoma cruzi

“…14 The biological activity of natural abietane acids has been reviewed. 15 In recent years, interest in these types of terpenoids has increased as a result of the isolation of compounds, mainly phenols and related derivatives, showing remarkable biological activities. [16][17][18] Other significant oxidized abietane diterpenes have shown strong inhibition of various human tumors and oncogen-transformed cells.…”