Aberrations in Pulmonary Function Due to Lymphangiography

Weg, John G.; Harkleroad, Lionel E.

doi:10.1378/chest.53.5.534

Cited by 18 publications

(4 citation statements)

References 13 publications

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“…No pulmonary symptoms may develop even after higher doses ) but pulmonary complications occurred in patients with underlying pulmonary disease (Bron et a/. 1963;Weg & Harkleroad 1968). The acute toxic effect of LipiodoP injected into the lymphatics of anaesthetized rabbits has been studied by Guiney et al (1964).…”

Section: Discussionmentioning

confidence: 99%

Studies on the Fate of Vegetable Oil after Intramuscular Injection into Experimental Animals

Svendsen

Aaes‐Jørgensen

1979

Acta Pharmacologica et Toxicologica

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The fate of sesame oil and Viscoleo was studied in dogs after single intramuscular injection into the thigh of 14C‐labelled oil (0.5 ml/kg). Parts of Viscoleo was absorbed as liquid oil to the regional lymph nodes occasionally to such an extent that small oil droplets were drained from the iliac lymph nodes into the lymph of the thoracic duct causing pulmonary oil microembolisation. Sesame oil was also absorbed to the regional lymph nodes after single injection but in no case to such an extent that pulmonary oil microembolism occurred. In dogs which received unlabelled sesame oil (0.45 and 1.0 ml/kg) or Viscoleo (0.45 ml/kg) intramuscularly once a week for six months and finally an injection of 14C‐labelled oil, pulmonary oil microembolism was seen in all three groups and most markedly after the higher sesame oil dose. The iliac lymph nodes in both sesame oil dose groups were highly enlarged and appeared cystic due to presence of oil. The lungs from the dogs receiving Viscoleo were seat of small mononuclear interstitial cell infiltrations sometimes present in the vicinity of oil microemboli. In the sesame oil groups oil was additionally found extravascularly in the lung interstities together with accumulation of macrophages and leucocytes and focal hemosiderosis in the lungs occurred on the highest dose level. In the sesame oil groups of dogs pulmonary oil microembolism was found microscopically in a higher number than that seen on autoradiograms. The embolisation obtained at one injection may thus not disappear before the next injection. Except for presence of very few oil microemboli and small focal areas with interstitial oil deposits the lungs were normal in dogs examined three months after six month chronic weekly injection of sesame oil. Small oil deposits were still present at the injection site and in the iliac lymph nodes of these dogs, but the lymphoid tissue of the nodes had partly recovered. Pulmonary oil microembolism was also seen microscopically in rabbits after intramuscular injection of sesame oil or Viscoleo three times a week for two weeks, and also in rats after injection of sesame oil three times a week for five weeks. The content of radioactivity in the heart, kidneys, liver and lungs were generally low and the liver had the highest content (up to 1.32% of dose). The content in the lungs was not increased by presence of Viscoleo microemboli whereas sesame oil microembolisation significantly raised the amount of radioactivity in the lungs. The amounts of radioactivity at the injection site of dogs were reduced to half of the injected dose two days after injection of 14C‐Viscoleo and five weeks after injection of 14C‐sesame oil. In rats receiving an intramuscular injection (0.5 ml) into the thigh of 14C‐Viscoleo or 14C‐sesame oil the amounts of radioactivity at the injection site disappeared exponentially with time, and half of the dose had disappeared one week after injection of 14C‐Viscoleo and 9 weeks after injection of 14C‐sesame oil. The acute intravenous toxicity of sesame oil a...

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Section: Discussionmentioning

confidence: 99%

Studies on the Fate of Vegetable Oil after Intramuscular Injection into Experimental Animals

Svendsen

Aaes‐Jørgensen

1979

Acta Pharmacologica et Toxicologica

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“…more likely, was the result of ventilation-perfusion discrepancies. Most studies have shown a reduction in diffusing capacity ranging from 15 to 30% [6,15,17,18], Physiologic-histologic correlations have suggested that early after injection, this reduction is largely the result of loss of pulmonary capillary bed from microemboli while later there may be a reduction in the membrane diffusing capacity from interstitial deposition of oil droplets and edema [6,19], A transient and largely reversible 'al veolar-capillary block' may go unnoticed in the healthy, but may be critical in patients with pre-existing impairment of respiratory gas ex change. Indeed, assessment of diffusing capacity before lymphography has been advised [6,15,17].…”

Section: Discussionmentioning

confidence: 99%

Respiratory Distress Syndrome Following Lymphangiography

Goff¹,

Gaensler²

1971

Respiration

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A patient is described who developed respiratory distress or a ‘stiff-lung syndrome’ following lymphangiography. There was no evidence of pre-existing lung disease. Excessive accumulation of the oily medium with liberation of fatty acids in the lung probably was the result of an early operative manipulation of the retroperitoneal lymphatic system. Follow-up lung function studies showed a persistent impairment of diffusing capacity. Pulmonary complications of lymphangiography are briefly reviewed

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“…However, it is not without risk. [71][72][73][74][75][76][77] It appears that the contrast medium, even if in just minute amounts, goes into the pulmonary arterioles in all patients. One study showed a decrease in the carbon monoxide diffusion in all patients receiving a lymphangiogram, 72 and another study showed persistence of this abnormality in the majority one year later.…”

Section: Intravenous Agentsmentioning

confidence: 99%

“…One study showed a decrease in the carbon monoxide diffusion in all patients receiving a lymphangiogram, 72 and another study showed persistence of this abnormality in the majority one year later. 73 There appear to be two different mechanisms of producing pulmonary disease from lymphograms. 76 The first mechanism is actual mechanical obstruction of the pulmonary arterial system.…”

Section: Intravenous Agentsmentioning

confidence: 99%

Miscellaneous Drug-Induced Pulmonary Disease

Rosenow¹

1980

Semin Respir Crit Care Med

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Aberrations in Pulmonary Function Due to Lymphangiography

Cited by 18 publications

References 13 publications

Studies on the Fate of Vegetable Oil after Intramuscular Injection into Experimental Animals

Studies on the Fate of Vegetable Oil after Intramuscular Injection into Experimental Animals

Respiratory Distress Syndrome Following Lymphangiography

Miscellaneous Drug-Induced Pulmonary Disease

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