Aberrant functional connectivity of the hippocampus in older adults with subthreshold depression

Zhu, Xinyi; Li, Rui; Wang, Pengyun; Li, Juan

doi:10.1002/pchj.60

Cited by 19 publications

(17 citation statements)

References 51 publications

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“…Previous studies found decreased hippocampal connectivity to frontal regions, which correlated with depression symptoms, specifically in StD subjects. 48 …”

Section: Discussionmentioning

confidence: 99%

Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

et al. 2015

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Subthreshold depression (StD) is a prevalent condition associated with social morbidity and increased service utilization, as well as a high risk of developing into a major depressive disorder (MDD). The lack of well-defined diagnostic criteria for StD has limited research on this disorder, with very few brain-imaging studies examining the neurobiology of StD. Yet, identifying the neural pathology of StD has the potential to elucidate risk factors and prognostic markers for major depression and is crucial for developing tailored treatments for patients at mild stages of depression. We investigated resting-state functional connectivity (rs-FC) of the cognitive control network (CCN), known to be dysregulated in MDD, using the bilateral dorsolateral prefrontal cortex (DLPFC) as a seed, focusing on two cohorts of StD subjects (young and middle aged) as well as matched controls. Irrespective of age, we found a significant rs-FC decrease in the CCN of the StD subjects, compared with matched controls, particularly between the DLPFC and the brain regions associated with the representation of self and other mental states (temporo-parietal junction (TPJ) and precuneus), as well as salience detection and orienting (insula). The functional connectivity between the DLPFC and the left TPJ was also associated with depressive symptom scores measured by the Center for Epidemiologic Studies Depression Scale. This finding may shed light on the neural pathology of StD, leading to better understanding of mild stages of depression, its diagnosis and the development of new treatments.

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“…Previous studies found decreased hippocampal connectivity to frontal regions, which correlated with depression symptoms, specifically in StD subjects. 48 …”

Section: Discussionmentioning

confidence: 99%

Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

et al. 2015

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“…One study confirmed that the functional connectivity of the hippocampus to the prefrontal and cuneus cortices decreased substantially in older adults with sub-threshold depression. Besides, the strength of hippocampus-cuneus connectivity was correlated with selfreported depressive symptoms [40]. This indicates that dysfunctional integration within the hippocampus and the cortical regions may involve in the occurrence of depression.…”

Section: The Role Of Neural Circuitry In Other Brain Regions Under a mentioning

confidence: 81%

“…Recent studies documented that the dysfunction of the neural circuits between the prefrontal and bilateral parietal cortex was associated with cognitive impairment in depression [51] [52]. The role of individual neural circuitry between different brain regions in depression was further emphasized by the relationship between the strength of hippocampus-cuneus connectivity and self-reported depressive symptoms in elderly individuals with sub-threshold depression [40]. These studies indicate the neural circuitry mechanism of depression is likely due to the elaborate interactions between the individual neural circuitry in different brain regions, even in the whole brain networks [53].…”

Section: Perspectivesmentioning

confidence: 99%

A Short Glance at the Neural Circuitry Mechanism Underlying Depression

Lu¹,

Li²,

Li³

et al. 2016

WJNS

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Depression leads to a large social burden because of its substantial impairment and disability in everyday activities. The prevalence and considerable impact of this disorder call for a better understanding of its pathophysiology to improve the diagnosis, treatment and prevention. Though productive animal models and pathophysiological theories have been documented, it is still very far to uncover the complex array of symptoms caused by depression. Moreover, the neural circuitry mechanism underlying behavioral changes in some depression-like behavior animals is still limited. Changes in the neural circuitry of amygdala, dorsal raphe nucleus, ventral tegmental area, hippocampus, locus coeruleus and nucleus accumbens are related to depression. However, the interactions between individual neural circuitry of different brain areas, have not yet been fully elucidated. The purpose of the present review is to examine and summarize the current evidence for the pathophysiological mechanism of depression, with a focus on the neural circuitry, and emphasize the necessity and importance of integrating individual neural circuitry in different brain regions to understand depression.

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“…Great efforts have been made during the past decades with an aim to decipher the underlying mechanism of this mental disease [5][6][7][8][9][10][11]. The occurrence of depression was usually accompanied with several changes in the prefrontal limbic areas which mainly involved the orbitofrontal cortex, insula, anterior and posterior cingulate cortex, hippocampus, amygdala and thalamus [12,13].…”

Section: Introductionmentioning

confidence: 99%

A Short Glance at the Role of Olfaction in Depression

Zhou¹,

Lu²,

Lin³

et al. 2017

Arch Depress Anxiety

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Depression as one kind of neuropsychiatric disorder affects tons of population in the world and exerts great economic and social burden. Great efforts have been made during the past decades aiming to decipher the underlying mechanism of this mental disease. Different kinds of mechanisms underlie depression, among which malfunctions in the olfactory system is one important reason. The occurrence of depression has a close association with dysfunctions in the olfactory system, which is highlighted by some brain regions responsible for depression overlapping with areas playing crucial roles in olfaction. The close relationship between olfactory malfunctions and depression is also underscored by the evidence that some patients with depression exhibited a higher probability of odor identifi cation impairment and a reduced olfactory sensitivity as well as smaller olfactory bulb volumes. For reasons of concise and clarity, in the current review we only briefl y summarized some key recent studies pertaining to the relationship between the dysfunctional olfaction and depression, to underscore potentially crucial roles of the normal olfactory system function in ameliorating the probability of the occurrence of depression.

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Aberrant functional connectivity of the hippocampus in older adults with subthreshold depression

Cited by 19 publications

References 51 publications

Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

Subthreshold depression is associated with impaired resting-state functional connectivity of the cognitive control network

A Short Glance at the Neural Circuitry Mechanism Underlying Depression

A Short Glance at the Role of Olfaction in Depression

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