Aberrant brain functional network strength related to cognitive impairment in age-related hearing loss

Abstract

PurposeAge-related hearing loss (ARHL) is a major public issue that affects elderly adults. However, the neural substrates for the cognitive deficits in patients with ARHL need to be elucidated. This study aimed to explore the brain regions that show aberrant brain functional network strength related to cognitive impairment in patients with ARHL.MethodsA total of 27 patients with ARHL and 23 well-matched healthy controls were recruited for the present study. Each subject underwent pure-tone audiometry (PTA), MRI scanning, and cognition evaluation. We analyzed the functional network strength by using degree centrality (DC) characteristics and tried to recognize key nodes that contribute significantly. Subsequent functional connectivity (FC) was analyzed using significant DC nodes as seeds.ResultsCompared with controls, patients with ARHL showed a deceased DC in the bilateral supramarginal gyrus (SMG). In addition, patients with ARHL showed enhanced DC in the left fusiform gyrus (FG) and right parahippocampal gyrus (PHG). Then, the bilateral SMGs were used as seeds for FC analysis. With the seed set at the left SMG, patients with ARHL showed decreased connectivity with the right superior temporal gyrus (STG). Moreover, the right SMG showed reduced connectivity with the right middle temporal gyrus (MTG) and increased connection with the left middle frontal gyrus (MFG) in patients with ARHL. The reduced DC in the left and right SMGs showed significant negative correlations with poorer TMT-B scores (r = −0.596, p = 0.002; r = −0.503, p = 0.012, respectively).ConclusionThese findings enriched our understanding of the neural mechanisms underlying cognitive impairment associated with ARHL and may serve as a potential brain network biomarker for investigating and predicting cognitive difficulties.

Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation

“…Interestingly, the supramarginal gyrus is involved in brain functions of receiving auditory inputs and phonological processing and the volume of grey matter in the right supramarginal gyrus was negatively associated with HD 43 . Similarly, a case-control study found that age-related hearing loss patients had deceased connectivity in the bilateral supramarginal gyrus 44 . In previous studies, individuals with HD showed a decreased volume in superior temporal gyrus, transverse temporal gyrus, and posterior superior temporal gyrus 14,15,45 .…”