Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging

Wilson, Tony W.; Lew, Brandon J.; Spooner, Rachel K.; Rezich, Michael T; Wiesman, Alex I.

doi:10.1016/bs.pmbts.2019.04.008

Cited by 14 publications

(8 citation statements)

References 94 publications

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“…Declines in neural efficiency are thought to be highly prevalent in PWH, including greater activation in the frontoparietal, default mode, and dorsal attention networks (Anteraper et al, 2021;Chang et al, 2001Chang et al, , 2004Meade et al, 2016), as well as elevated (i.e., less optimal) spontaneous cortical activity, which refers to the seemingly random neuronal discharges, fluctuations in dendritic currents, and other electrical field phenomena that occur across the cortex in the absence of endogenous and exogenous stimuli (Casagrande et al, 2021;Lew et al, 2018Lew et al, , 2020Spooner et al, 2018Spooner et al, , 2020Wiesman et al, 2018;Wilson et al, 2019). In particular, PWH have elevated levels of spontaneous theta (~4-8 Hz) and alpha (~8-14 Hz) activity, along with blunted (i.e., less optimal) theta and alpha oscillations (Lew et al, 2018;Wiesman et al, 2018;Wilson et al, 2019). Such altered neural oscillatory activity has been associated with impaired cognitive performance.…”

Section: Introductionmentioning

confidence: 99%

Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control

et al. 2022

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Background: Cannabis use and HIV are independently associated with decrements in cognitive control. However, the combined effects of HIV and regular cannabis use on the brain circuitry serving higher-order cognition are unclear. Aims: Investigate the interaction between cannabis and HIV on neural interference effects during the flanker task and spontaneous activity in regions underlying higher-order cognition. Methods: The sample consisted of 100 participants, including people with HIV (PWH) who use cannabis, PWH who do not use cannabis, uninfected cannabis users, and uninfected nonusers. Participants underwent an interview regarding their substance use history and completed the Eriksen flanker task during magnetoencephalography (MEG). MEG data were imaged in the time–frequency domain and oscillatory maps depicting the neural flanker interference effect were probed for group differences. Voxel time series were then assessed for group-level differences in spontaneous activity. Results: Group differences in behavioral performance were identified along with group differences in theta and alpha neural interference responses in higher-order regions across the cortex, with nonusers with HIV generally exhibiting the most aberrant responses. Likewise, time series analyses indicated that nonusers with HIV also had significantly elevated spontaneous alpha activity in the left inferior frontal and dorsolateral prefrontal cortices (dlPFC). Finally, we found that spontaneous and oscillatory alpha activity were significantly coupled in the inferior frontal cortex and dlPFC among cannabis users, but not nonusers. Conclusions: Regular cannabis use appears to suppress the impact of HIV on spontaneous and oscillatory alpha deficits in the left inferior frontal cortex and dlPFC.

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Section: Introductionmentioning

confidence: 99%

Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control

et al. 2022

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“…A growing body of studies have employed neuroimaging techniques to understand the effects of HIV‐infection on the brain (Ances et al, 2009; Ances et al, 2010; Ances, Vaida, Ellis, & Buxton, 2011; Chang et al, 2004; Chang, Yakupov, Nakama, Stokes, & Ernst, 2008; Ernst, Chang, Jovicich, Ames, & Arnold, 2002; Spooner et al, 2018; Wiesman et al, 2018; Wilson, Fox, et al, 2013; Wilson, Heinrichs‐Graham, et al, 2013, 2016; Wilson, et al, 2017, 2019). These studies have shown that HIV‐infection has an extensive effect on both brain structure (Klunder et al, 2008; Sanford et al, 2017; Sanford, Fellows, Ances, & Collins, 2018; Wilson et al, 2015) and function (Simioni et al, 2009; Spooner et al, 2018; Spooner et al, 2020), although the degree to which such structural abnormalities directly translate into functional brain aberrations is unclear.…”

Section: Introductionmentioning

confidence: 99%

Impact of HIV‐infection on human somatosensory processing, spontaneous cortical activity, and cortical thickness: A multimodal neuroimaging approach

Casagrande

Lew

Taylor

et al. 2021

Human Brain Mapping

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HIV‐infection has been associated with widespread alterations in brain structure and function, although few studies have examined whether such aberrations are co‐localized and the degree to which clinical and cognitive metrics are related. We examine this question in the somatosensory system using high‐resolution structural MRI (sMRI) and magnetoencephalographic (MEG) imaging of neural oscillatory activity. Forty‐four participants with HIV (PWH) and 55 demographically‐matched uninfected controls completed a paired‐pulse somatosensory stimulation paradigm during MEG and underwent 3T sMRI. MEG data were transformed into the time‐frequency domain; significant sensor level responses were imaged using a beamformer. Virtual sensor time series were derived from the peak responses. These data were used to compute response amplitude, sensory gating metrics, and spontaneous cortical activity power. The T1‐weighted sMRI data were processed using morphological methods to derive cortical thickness values across the brain. From these, the cortical thickness of the tissue coinciding with the peak response was estimated. Our findings indicated both PWH and control exhibit somatosensory gating, and that spontaneous cortical activity was significantly stronger in PWH within the left postcentral gyrus. Interestingly, within the same tissue, PWH also had significantly reduced cortical thickness relative to controls. Follow‐up analyses indicated that the reduction in cortical thickness was significantly correlated with CD4 nadir and mediated the relationship between HIV and spontaneous cortical activity within the left postcentral gyrus. These data indicate that PWH have abnormally strong spontaneous cortical activity in the left postcentral gyrus and such elevated activity is driven by locally reduced cortical gray matter thickness.

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“…While these and other fMRI and structural MRI studies have identified the brain regions and networks most susceptible to the effects of the disease [27] , [28] , [29] , [30] , more recently, the neural dynamics have become an increasing area of focus. In fact, both resting-state and task-based magnetoencephalography (MEG) studies have substantially enhanced our understanding of the pathophysiology, as they enable direct quantification of neurophysiology with excellent temporal resolution and good spatial precision, as opposed to other neuroimaging modalities that measure brain activity indirectly [31] , [32] , [33] .…”

Section: Introductionmentioning

confidence: 99%

The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study

et al. 2020

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Background Despite living a normal lifespan, at least 35% of persons with HIV (PWH) in resource-rich countries develop HIV-associated neurocognitive disorder (HAND). This high prevalence of cognitive decline may reflect accelerated ageing in PWH, but the evidence supporting an altered ageing phenotype in PWH has been mixed. Methods We examined the impact of ageing on the orienting of visual attention in PWH using dynamic functional mapping with magnetoencephalography (MEG) in 173 participants age 22–72 years-old (94 uninfected controls, 51 cognitively-unimpaired PWH, and 28 with HAND). All MEG data were imaged using a state-of-the-art beamforming approach and neural oscillatory responses during attentional orienting were examined for ageing, HIV, and cognitive status effects. Findings All participants responded slower during trials that required attentional reorienting. Our functional mapping results revealed HIV-by-age interactions in left prefrontal theta activity, alpha oscillations in the left parietal, right cuneus, and right frontal eye-fields, and left dorsolateral prefrontal beta activity ( p <.005). Critically, within PWH, we observed a cognitive status-by-age interaction, which revealed that ageing impacted the oscillatory gamma activity serving attentional reorienting differently in cognitively-normal PWH relative to those with HAND in the left temporoparietal, inferior frontal gyrus, and right prefrontal cortices ( p <.005). Interpretation This study provides key evidence supporting altered ageing trajectories across vital attention circuitry in PWH, and further suggests that those with HAND exhibit unique age-related changes in the oscillatory dynamics serving attention function. Additionally, our neural findings suggest that age-related changes in PWH may serve a compensatory function. Funding National Institutes of Health, USA.

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Aberrant brain dynamics in neuroHIV: Evidence from magnetoencephalographic (MEG) imaging

Cited by 14 publications

References 94 publications

Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control

Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control

Impact of HIV‐infection on human somatosensory processing, spontaneous cortical activity, and cortical thickness: A multimodal neuroimaging approach

The age-related trajectory of visual attention neural function is altered in adults living with HIV: A cross-sectional MEG study

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