Biochemical Pharmacology volume 81, issue 4, P488-497 2011 DOI: 10.1016/j.bcp.2010.11.007 View full text
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Yongmao Yu, Yicheng Zhang, Ziping Zhu, Stuart A. Berger

Abstract: ABC50 (aka ABCF1) is a member of the ATP Binding Cassette protein family. ABC50 stimulates complex formation between eIF2, GTP and Met-tRNA implicating it in translation initiation. Econazole (Ec) is an imidazole anti-fungal that induces endoplasmic reticulum (ER) stress in mammalian cells by promoting ER Ca(2+) depletion and sustained protein synthesis inhibition. HL60 cells selected for Ec resistance were found to exhibit a multi-drug resistance phenotype associated specifically with ER stress. Differential …

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