AB1199 Anxiety is associated with antiribosomal p antibody in childhood-onset systemic lupus erythematosus

Abstract

Objectives To investigate the prevalence of the anti-ribosomal P (anti-P) antibodies in childhood-onset systemic lupus erythematosus patients (cSLE) and to elucidate the association between anti-P and disease activity, laboratory and treatment features in cSLE patients Methods We included consecutive SLE patients with disease onset before the age of 16 (cSLE), first-degree relatives and age and healthy age and sex matched controls. cSLE patients were assessed for disease activity [SLE Disease Activity Index (SLEDAI)], damage [Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)] and current drug exposures. Mood disorders were determined through Becks Depression and Becks Anxiety Inventory (BDI and BAI). Anti-P was measured by enzyme-linked immunosorbent assay using commercial kits. Clinical/laboratorial manifestations, disease activity, cumulative damage and drugs undertaken were assessed at time of blood withdrawal Results We included 50 cSLE patients (mean age 16.82±3.46), 35 first-degree relatives (mean age 38.73±3.89) and 20 health controls (mean age 18.3±4.97). Anti-P was present in 13 (26%) cSLE patients. No first-degree relatives or controls presented anti-P (p<0.01). The presence of anti-P was associated with anxiety on cSLE (p<0,002). No other clinical/laboratorial manifestations or treatment were associated with anti-P in cSLE. Conclusions Anti-P is frequently observed in cSLE patients and was associated with anxiety in this cohort. Grants FAPESP: 2008/02917-0; 2009/13046-3 Disclosure of Interest H. Aldar Grant/Research support from: FAPESP 2009/13046-3, A. Lapa Grant/Research support from: FAPESP 2010/13639-1, B. Belini Grant/Research support from: FAPESP 2009/12343-4, N. Sinicato Grant/Research support from: FAPESP 2010/13637-9, M. Postal Grant/Research support from: FAPESP 2009/10744-1, P. Fernandes: None Declared, L. Costallat: None Declared, R. Marini: None Declared, S. Appenzeller Grant/Research support from: FAPESP 2008/02917-0; Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (300447/2009-4)