AB1012 Clinical utility of antihistone antibodies: a descriptive study

Abstract

BackgroundAntihistone antibodies (AHA) have been linked to Drug-Induced Lupus Erythematosus (DILE) for decades1. However, for some authors this relationship is not so clear and sugest that the presence of these autoantibodies is related to other autoimmune diseases more frequently2,3,4.ObjectivesThe main objetive of this work was to study the association of AHA with different autoimmune entities (including DILE) and secondarily, look into which clinical manifestations and which autoantibodies are more frequently related to AHA.MethodsWe performed a descriptive study. A database was constituted using all patients with AHA+ in any blood analysis between years 2000 and 2016 in the University Hospital Complex of Vigo. The variables of the study were: presence of autoimmune disease, clinical manifestations and related autoantibodies.ResultsVariableMenWomenAll% Total Age504546Gender155873100SLE8273548DILE0000Scleroderma0445Sjögren18912Rheumatoid Arthritis0334No diagnosis5192433Malar rash1111216Photosensitivity2111318Oral ulcers1101115Arthritis6313751Lupic nephropathy4131723Raynaud1111216Hematological abnormalities5202534AntiRo+4121622AntiLa+25710AntiSm+381115AntiDNAds+3252838None of the 73 patients AHA+ developed DILE while almost the 50% of them suffer any other autoimmune disease. We found a high percentage of AHA+ patients with lupus erythematous complications such as arthritis and hematological abnormalities. AntiDNAds antibody was the more frequent coexpressed autoantibody.Conclusions AHA detection is not useful as DILE screening.AHA+ sugest the presence of other autoimmune disease rather than DILE.AHA+ may be related to lupus erythematous systemic complications. References Fritzler MJ, Tan EM. Antibodies to histone in drug-induced and idiopathic lupus erythematosus. J Clin Invest. 1978;62:560–567.Peng SL, Craft J. Antinuclear antibodies. In: Ruddy S, Harris ED, Sledge CB, eds. Kelley's Textbook of Rheumatology. 6th ed. Philadelphia, Pa: WB Saunders; 2001:166.Kubo M, Ihn H, Yasawa N, et al. Prevalence and antigen specificity of antihistone antibodies in patients with polymyositis/dermatomyositis. J Invest Dermatol. 1999;112:711–715.Zirwas MJ, Kress DW, Deng JS. The Utility of Antihistone Antibody Screening in the Diagnosis of Drug-Induced Lupus Erythematosus. Arch Dermatol Apr 2004; VOL 140: 494–495. Disclosure of InterestNone declared

A Rare Case of Malignant Mesothelioma Presenting with Systemic Lupus Erythematosus Seropositivity: A Case Report and Review of Literature

“…On the other hand, approximately half of patients did develop another form of autoimmune disease, such as SLE or Sjogren’s syndrome. Coincidentally, it was noted that anti-dsDNA antibodies were the most commonly co-expressed rheumatologic marker in AHA positive patients [13]. It is also important to recognize multiple subtypes of histones.…”

The effect of amaranth oil on autoantibodies in lupus prone mice

“…Similarly, antinucleosome antibodies are associated with SLE, rheumatoid arthritis, Sjögren's syndrome, and systemic sclerosis [15,17,[20][21]. Anti-histone antibodies have been associated with SLE, rheumatoid arthritis, systemic sclerosis, Alzheimer's disease, dementia, autoimmune hepatitis, druginduced lupus, primary biliary cirrhosis, infection, as well as linear sclerosis severity [15,17,[22][23][24][25]. Anti single-stranded (ss) DNA antibodies are an indicator of flares in SLE, linear sclerosis severity, and have been correlated to preeclampsia and malaria [24,[26][27][28].…”