AB0845 Technetium-99 conjugated with methylene diphosphonate ameliorates glucocorticoid induced osteoporosis in rats

Abstract

Results: 15 patients were included: 11 women and 4 men, with a mean age of 42.2 years (SD+/-16) The genetic study was performed in 12 patients: 75% were positive for HLA DQ2 and 25% for HLA DQ8. The determination of antibodies was positive in 12 patients (73%) and negative in 3 (27%). These 3 were positive for the genetic study (2 HLA DQ2 and 1 HLA DQ8). The study of BD showed: type I in 4 patients; Type IIIa in 2 patients; Type IIIb in 6 patients; Type IIIC in 3 patients. BMD showed normal values in 33%, osteopenia in 47% and osteoporosis (OP) in 20% of patients. Thus, 67% had an alteration in BMD at the time of diagnosis. 100% had a Vit D deficit, with a mean value of 14.3 ng/mL (range 4.15-26.8). 75% of them had values below 20 ng/mL (40% less than 10 ng/mL). 40% had secondary hyperparathyroidism (SHP), 83% of which had an alteration in BMD (67% osteopenia and 16% OP). The BD of the patients with SHP and alteration of the BMD showed a histological pattern type Marsh III. No patient presented an alteration in the values of calcemia, phosphataemia or calciuria. The relationship between the degree of alteration in BMD and the Marsh classification (table) was studied. 72% of patients with a Marsh III had an alteration in BMD (3 OP and 5 osteopenia vs 3 normal).