AB084. The circulating serotypes of dengue in Sabah, Malaysian Borneo

Najri, Nadia Iryani; Mazlan, Zulina; Jaimin, Joel Judson; Mohammad, Rashidah; Mohd, Tajul Ariffin Awang; Hameed, Ahneez Abdul; Subbiah, Vijay Kumar; Hoque, Muhammad Ziaul

doi:10.21037/atm.2017.s084

Cited by 2 publications

(3 citation statements)

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“…This supports the hypothesis that the virus strain and small genotypic changes may be important modifying factors for severity, and hence, phylogenetic analysis is important when interpreting serotype-specific data [14]. The early detection of circulating serotypes could be an important approach to prevent severe clinical outcomes during dengue outbreaks [15]. This is important not only for dengue-endemic countries but also from the clinical aspect in non-endemic countries.…”

Section: Discussionsupporting

confidence: 61%

“…The majority of dengue cases were adults (603/ 1351, 44.6%), followed by adolescents (405/1351, 30.0%), and children (343/1351, 25.4%). According to Najri et al [15], for age categories, adults were defined as those 20 years and above, adolescents were 10-19 years old, and children were under 19 years old.…”

Section: Dengue Cases From Multiple Sitesmentioning

confidence: 99%

“…A similar pattern of increasing trend of dengue infection is also observed in Sabah which needs immediate measures to assess this regional issue. However, data on the serotype distribution in Sabah is still lacking [15]. This requires a comprehensive study on the epidemiology and circulating serotypes in Sabah to determine whether they are associated with increased virulence or whether other associated factors are responsible.…”

Section: Introductionmentioning

confidence: 99%

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The east coast districts are the possible epicenter of severe dengue in Sabah

Kaur¹,

Rahim²,

Jaimin³

et al. 2020

J Physiol Anthropol

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Background: Malaysia recorded the highest number of dengue cases between 2014 and 2017. There are 13 states and three federal territories in Malaysia, and each area varies in their prevalence of dengue. Sabah is one of the states situated in Borneo, Malaysia. Although dengue has been increasing for the last several years, no study was being done to understand the burden and serotype distribution of the dengue virus (DENV) in Sabah. Therefore, the present study was carried out to understand the epidemiology of the dengue infection and the factors responsible for severe dengue in Sabah. Methods: Data on dengue infection were extracted from the dengue database of the state of Sabah from 2013 through 2018. DENV NS-1-positive serum samples from multiple sites throughout Sabah were sent to the state public health laboratory, Kota Kinabalu Public Health Laboratory, for serotype determination. The analysis of factors associated with severe dengue was determined from the data of 2018 only. Results: In 2013, there were 724 dengue cases; however, from 2014, dengue cases increased exponentially and resulted in 3423 cases in 2018. Increasing dengue cases also led to increased dengue mortality. The number of dengue deaths in 2013 was only five which then gradually increased, and in 2018, 29 patients died. This is an increase of 580% from 2013 to 2018. Deaths were considerably more in the districts of the east coast of Sabah compared with districts in the west coast. During the study period, all DENV serotypes could be identified as serotypes circulating in Sabah. In 2018, the predominant serotype was DENV-3. The monthly peak of dengue infection varied in different years. In the logistic regression analysis, it was identified that children were 6.5 times, patients infected with mixed serotype of DENV were 13 times, and cases from the districts of the east coast were 5.2 times more likely to develop severe dengue. Conclusions: An increasing trend of dengue infection has been observed in Sabah. The burden of dengue, severe dengue, and mortality was noted especially in the districts of the east coast of Sabah. Severe dengue was most likely developed in children, cases from the east coast, and patients infected with mixed serotype of DENV.

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Section: Discussionsupporting

confidence: 61%

Section: Dengue Cases From Multiple Sitesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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