Abstracts Accepted for Publication 2017
DOI: 10.1136/annrheumdis-2017-eular.6015 View full text |Buy / Rent full text
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Abstract: BackgroundTryptophan (TRYP) can be converted to kynurenine (KYN) by indoleamine 2,3-dioxygenase (IDO) drived by interferon-γ. Recent studies have suggested that the KYN pathway reflects an important interface between the immune and nervous system modulation.ObjectivesThe aim was to study KYN pathway and their correlation to clinical and immunological parameters in primary Sjögren's syndrome (pSS).MethodsWe included 97 pSS (AECG) and 63 healthy controls matched to age, sex, ethnicity, and body mass index (BMI).… Show more

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“…Those facts allow us to exam the relationship among TKP, neurologic manifestations and autoimmune diseases like SS. to monitor the changes in the CNS, more specifically in the hippocampus [43,132,178,179] Not only SS patients but also individuals exposed to chronic stress present signs of hippocampal structure and NMDA signaling changes [27,180].…”
Section: The Tkp and The Neurologic Manifestationsmentioning
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“…Those facts allow us to exam the relationship among TKP, neurologic manifestations and autoimmune diseases like SS. to monitor the changes in the CNS, more specifically in the hippocampus [43,132,178,179] Not only SS patients but also individuals exposed to chronic stress present signs of hippocampal structure and NMDA signaling changes [27,180].…”
Section: The Tkp and The Neurologic Manifestationsmentioning
“…In other words, we hypothesized that SS patients with Interferon-γ (IFN-γ)-inducible TKP activation could develop chronic pain and low EGM disease activity because the TKP promotes an immunosupressive and neuro sensitive effect. Therefore IFN-γ-inducible TKP could be the missing link between disease activity and neural manifestations in SS [43] (Figure 1).…”
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