Abstract:BackgroundInterferon-alpha (IFNα) pathway has a crucial role in the pathogenesis of SLE. Many genes have been encoding with this pathway and their impaired expression have been reported in patients with SLE. TREX1 is a DNA exonuclease involved in the metabolism and clearance of single stranded DNA from apoptotic cells, which is impaired in SLE1. TREX1 mutations have been reported in SLE2.ObjectivesOur study was aiming to assess the role of TREX1 in the genetic susceptibility to systemic lupus erythematosus (SL… Show more
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