AACE2021-A-1033: Primary Thyroid Lymphoma: Case Series of Patients from a Developing Country

Khan, Sajjad; Aziz, Abdul; Ali, Dania; Islam, Najmul

doi:10.1016/j.eprac.2021.11.047

Cited by 1 publication

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“…The prognosis of PTL varies widely depending on the lymphoma subtype, disease stage at diagnosis, and the patient's overall health. There are several case reports, case series and comprehensive reviews in the literature [1,2,7,12,21,[30][31][32], but original studies presenting prognostic data on a relatively high number of patients are scarce. The SEER database estimates a median overall survival of 9.3 years for PTL patients.…”

Section: Discussionmentioning

confidence: 99%

Primary Thyroid Lymphoma: A Nationwide Retrospective Cohort Analysis of Survival and Determinant Factors

Koseoglu,

GUNES,

KAYA

et al. 2023

Preprint

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Purpose This study aims to analyze survival rates and determinant factors in patients diagnosed with primary thyroid lymphoma, a rare subtype of thyroid cancer. Methods We conducted a retrospective analysis of 57 primary thyroid lymphoma cases from fourteen tertiary care hospitals over a span of 22 years. Patient demographics, clinical presentations, treatment regimens, and outcomes were reviewed. Survival analysis was performed using Kaplan-Meier and Cox regression models. Results The majority of patients were middle-aged and older women, with a mean age of 60. Diffuse large B-cell lymphoma was the predominant histological subtype. The median overall survival was 163 months, with a 5-year survival rate of 69.2%. Treatment primarily involved R-CHOP chemotherapy, with 81.1% achieving a complete response. Tracheal compression and age were identified as independent prognostic factors for survival. Conclusion Primary thyroid lymphoma predominantly affects older women and is commonly diagnosed as diffuse large B-cell lymphoma. The data suggest that age and tracheal compression significantly influence patient survival, emphasizing the importance of these factors in the management and prognosis of primary thyroid lymphoma.

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