2015
DOI: 10.1136/annrheumdis-2015-207259.106
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Abstract: Background/Purpose Osteoarthritis (OA) is the leading cause of chronic disability affecting 40% of individuals over the age of 70 and costing $128 billion annually in the US alone. Little is known regarding changes in gene expression that occur regionally within these affected joints. Herein, we perform RNA-seq analysis of eroded and intact cartilage from human OA, and correlate transcript levels with histopathologic disease severity. Methods Six femoral heads were obtained at the time of hip arthroplasty fo… Show more

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“…Osteoarthritis (OA) is a complex degenerative joint disease especially prevalent in the elderly. Temporomandibular joint osteoarthritis (TMJ‐OA) is an important subtype of temporomandibular disorders (Cledes, Felizardo, Foucart, & Carpentier, ; Jeffries et al., ). TMJ‐OA is mainly characterised by condylar dysplasia, cartilage degradation and subchondral bone resorption (Ikeda, Yonemitsu, Takei, Shibata, & Ono, ; Wang et al., ).…”
Section: Introductionmentioning
confidence: 99%
“…Osteoarthritis (OA) is a complex degenerative joint disease especially prevalent in the elderly. Temporomandibular joint osteoarthritis (TMJ‐OA) is an important subtype of temporomandibular disorders (Cledes, Felizardo, Foucart, & Carpentier, ; Jeffries et al., ). TMJ‐OA is mainly characterised by condylar dysplasia, cartilage degradation and subchondral bone resorption (Ikeda, Yonemitsu, Takei, Shibata, & Ono, ; Wang et al., ).…”
Section: Introductionmentioning
confidence: 99%