volume 39, issue 2, P190-197 2008
DOI: 10.1165/rcmb.2007-0450oc
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Abstract: Adenosine (ADO) signaling is altered in both asthma and chronic obstructive pulmonary disease, and the A 2B adenosine receptor (A 2B -R) may drive pulmonary inflammation. Accordingly, it has been proposed that specific inhibition of the A 2B -R could treat inflammatory lung diseases. However, stimulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by ADO may be crucial in permitting the superficial epithelium to maintain airway surface liquid (ASL) volume, which is required to ensure hyd…

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