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Cited by 156 publications
(98 citation statements)
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References 28 publications
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“…Moreover, the development of a physiologically functional liver in zebrafish is very rapid, in comparison to other vertebrate models (14). Zebrafish complete primary liver morphogenesis by 48 h postfertilization (hpf), and the liver is perfused with blood and becomes fully functional by 72 hpf (15).…”
mentioning
confidence: 99%
“…Moreover, the development of a physiologically functional liver in zebrafish is very rapid, in comparison to other vertebrate models (14). Zebrafish complete primary liver morphogenesis by 48 h postfertilization (hpf), and the liver is perfused with blood and becomes fully functional by 72 hpf (15).…”
mentioning
confidence: 99%
“…However, there is a lack of information regarding the anti-inflammatory activities and toxicity of soft corals in vivo model. Recent studies have reported that zebrafish was used to rapidly and simply assess the anti-inflammatory activity against LPS-stimulated inflammation and toxicity (Park and Cho 2011;He et al 2013). Hence, the aim of the present investigation was to evaluate the toxicity and anti-inflammatory effect of the soft coral D. gigantea extract (SCDE) in the zebrafish embryo in vivo model.…”
Section: Discussionmentioning
confidence: 99%
“…Due to these advantages, recently, the value of the zebrafish as a model organism for in vivo drug toxicity and efficacy studies has been recognized (den Hertog 2005; Ali et al 2011;He et al 2013). In addition, the optical transparency of zebrafish embryos allows noninvasive and dynamic imaging the inflammation in vivo.…”
Section: Introductionmentioning
confidence: 99%
“…With 48 hr treatment from 72 to 120 hpf, the larval were visually observed for imaging acquisition of specific phenotypic endpoints under the dissecting stereomicroscope installed with a high-speed video camera. As described by He et al, the larval liver is approximately globular in structure with a clearly recognizable periphery against the neighboring tissues and is perfused with circulating blood cells (He et al, 2013). The normal liver is clear, whereas the hepatotoxicity attacked liver becomes darker with a brown or gray coloration and the texture of liver tissue becomes amorphous undergoing degeneration and/or necrosis (McGrath and Li, 2008;Hill et al, 2012).…”
Section: Hepatotoxicity Assessmentmentioning
confidence: 96%
“…Morphologically, massive hepatocellular necrosis can result in smaller, dark livers owing to the loss of transparency and these have been suggested as a phenotypic endpoint for assessing hepatotoxicity (Hill et al, 2012). When exposed to a hepatotoxicant, changes to liver morphology can be evaluated visually since larval zebrafi sh is virtually transparent (Hill et al, 2012;He et al, 2013). The unique nature of larval zebrafi sh presented above makes this animal an attractive model to study DIHT, being capable of mimicking the complexity of the whole liver system in humans.…”
Section: Introductionmentioning
confidence: 99%