A xanthanolide from Xanthium strumarium

Saxena, Vipin; Mondal, Sourav

doi:10.1016/s0031-9422(00)90678-2

Cited by 23 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Xarithium strumarium L. (Asteraceae, tribe Heliantheae, subtribe Ambrosiinae) has been used in folk medicine for treating leucoderma, fever, scrofula, herpes, and cancer (1). Previous biochemical investigations led to the isolation of some compounds which have biological effects such as anticancer and hypoglycemic activity (1,2). Furthermore, several xanthanolide-type sesquiterpene lactones were the characteristic secondary metabolites of this species (1,(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Xanthanolides and Xanthane Epoxide Derivatives fromXanthium strumarium

Mahmoud¹

1998

Planta Med

View full text Add to dashboard Cite

From the aerial parts of Xanthium strumarium, three new xanthanolide and xanthane-type sesquiterpenoids, 11alpha,13-dihydroxanthatin, 4beta,5beta-epoxyxanthatin-1alpha,4alpha-endoperoxide, and 1beta,4beta,4alpha,5alpha-diepoxyxanth-11(13)-en-12-oic acid have been isolated, together with seven known compounds. The structures were determined by spectroscopic methods, particularly high resolution 1D, 2D NMR spectroscopy and NOE experiments.

show abstract

Section: Introductionmentioning

confidence: 99%

Xanthanolides and Xanthane Epoxide Derivatives fromXanthium strumarium

Mahmoud¹

1998

Planta Med

View full text Add to dashboard Cite

show abstract

“…Due to the presence of sesquiterpene lactones is related the potential anticancer activity (Roussakis & al. 1994;Saxena & Mondal 1994;Kim & al. 2003;Nibret & al.…”

Section: Contemporary Pharmacological Investigationsmentioning

confidence: 99%

Xanthium strumarium – a potential cheap resource of plant substances for medicinal use

Spadaro¹,

Йонкова

Kozuharova

2019

Fl. Medit.

View full text Add to dashboard Cite

Kozuharova, E., Ionkova, I. & Spadaro, V.: Xanthium strumarium -a potential cheap resource of plant substances for medicinal use . -Fl. Medit. 29: 93-102. 2019. -ISSN: 1120 printed, 2240-4538 online.Xanthium strumarium L. (Asteraceae) is an annual herb which reproduces solely by seed. So far its centre of origin was considered Central or South America. Recent archeological research revealed that the burs of X. strumarium were used in Yuergou site (400-200 cal BC) in the Turpan Basin of northwestern China. This plant adventive to Europe reduces germination of various crops and behaves like and aggressive invasive species. X. strumarium is the most frequently recorded plant in the field borders between the crop land and adjacent territories the agricultural areas in Bulgaria. We aim of this study is to reveal the potential of X. strumarium as a cheap source of compounds with valuable pharmacological activities. Here we analyse: 1) the traditional ethnobotanical data from its native habitats; 2) the modern investigations of pharmacological activity and essential secondary compounds. Traditionally the plant is used as febrifuge drug and an immunostimulant, as a diaphoretic agent and against malaria, as well as dysentry cure, astringent, sedative, analgesic, diuretic, against leucorrhoea and urinary diseases, eczema and skin disease, bleeding, insect bite, to treat boils and pimples, against smallpox and stomach diseases, earache and strumous disease, leprosy, headache, fever, etc. X. strumarium contains sesquiterpene lactones, thiazinediones, phenolic acids etc. and posses anticancer, antitussive, antifungal, antiinflammatory, antinociceptive, hypoglycaemic, antioxidant, antitrypanosomal, and antidepressant-like activity, diuretic effects, insecticidal and herbicidal activities as well as antitrypanosomal effect. A pharmaceutical application of this plant in the future would reduce its populations and thus would contribute to the biodiversity conservation.

show abstract

“…Xanthanolides are bicyclic STLs in which a five carbon-membered γ-lactone ring is fused to a seven carbon-membered carbocycle (Supplementary Figure 1). The richest source of xanthanolides is found in species of the genus Xanthium , which has been used as a Chinese traditional herb to treat leucoderma, scrofula, herpes, sinusitis, and cancer (Saxena and Mondal, 1994; Committee, 2005; Vasas and Hohmann, 2010). Xanthanolides are believed to be the active molecules that confer the medicinal effects of X. strumarium .…”

Section: Introductionmentioning

confidence: 99%

Comparative Transcriptome Analysis Identifies Putative Genes Involved in the Biosynthesis of Xanthanolides in Xanthium strumarium L.

Gou

Chen

et al. 2016

Front. Plant Sci.

View full text Add to dashboard Cite

Xanthium strumarium L. is a traditional Chinese herb belonging to the Asteraceae family. The major bioactive components of this plant are sesquiterpene lactones (STLs), which include the xanthanolides. To date, the biogenesis of xanthanolides, especially their downstream pathway, remains largely unknown. In X. strumarium, xanthanolides primarily accumulate in its glandular trichomes. To identify putative gene candidates involved in the biosynthesis of xanthanolides, three X. strumarium transcriptomes, which were derived from the young leaves of two different cultivars and the purified glandular trichomes from one of the cultivars, were constructed in this study. In total, 157 million clean reads were generated and assembled into 91,861 unigenes, of which 59,858 unigenes were successfully annotated. All the genes coding for known enzymes in the upstream pathway to the biosynthesis of xanthanolides were present in the X. strumarium transcriptomes. From a comparative analysis of the X. strumarium transcriptomes, this study identified a number of gene candidates that are putatively involved in the downstream pathway to the synthesis of xanthanolides, such as four unigenes encoding CYP71 P450s, 50 unigenes for dehydrogenases, and 27 genes for acetyltransferases. The possible functions of these four CYP71 candidates are extensively discussed. In addition, 116 transcription factors that are highly expressed in X. strumarium glandular trichomes were also identified. Their possible regulatory roles in the biosynthesis of STLs are discussed. The global transcriptomic data for X. strumarium should provide a valuable resource for further research into the biosynthesis of xanthanolides.

show abstract

A xanthanolide from Xanthium strumarium

Cited by 23 publications

References 15 publications

Xanthanolides and Xanthane Epoxide Derivatives fromXanthium strumarium

Xanthanolides and Xanthane Epoxide Derivatives fromXanthium strumarium

Xanthium strumarium – a potential cheap resource of plant substances for medicinal use

Comparative Transcriptome Analysis Identifies Putative Genes Involved in the Biosynthesis of Xanthanolides in Xanthium strumarium L.

Contact Info

Product

Resources

About