A WOX/Auxin Biosynthesis Module Controls Growth to Shape Leaf Form

Zhang, Zhongjuan; Runions, Adam; Mentink, Remco A.; Kierzkowski, Daniel; Karády, Michal; Hashemi, B. Kosar; Huijser, Peter; Strauss, Soeren; Gan, Xiangchao; Ljung, Karin; Tsiantis, Miltos

doi:10.1016/j.cub.2020.09.037

Cited by 86 publications

(84 citation statements)

References 56 publications

(99 reference statements)

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“…Similar to Arabidopsis WOX1 ‐ WOX7 repressor genes, LFL acts as a transcriptional repressor able to functionally replace STF during the development of either the flower or the leaf, provided that the gene is driven by the STF promoter (Lin et al, 2013a; Niu et al, 2015). Furthermore, WOX5 acts redundantly with WOX1 and PRS to control leaf growth (Zhang et al, 2020b). Loss of WOX5 in wox1wox3 double mutants led to a further reduction in leaf size and enhanced the narrow leaf defect (Zhang et al, 2020b).…”

Section: The Establishment and Maintenance Of Leaf Polaritymentioning

confidence: 99%

“…Furthermore, WOX5 acts redundantly with WOX1 and PRS to control leaf growth (Zhang et al, 2020b). Loss of WOX5 in wox1wox3 double mutants led to a further reduction in leaf size and enhanced the narrow leaf defect (Zhang et al, 2020b). WOX1, 3 , and 5 promote auxin synthesis and ectopic YUC1 expression partially restores the leaf size, which links the WOX homeobox proteins and the hormone auxin in the context of controlling leaf growth (Zhang et al, 2020b).…”

Section: The Establishment and Maintenance Of Leaf Polaritymentioning

confidence: 99%

“…Loss of WOX5 in wox1wox3 double mutants led to a further reduction in leaf size and enhanced the narrow leaf defect (Zhang et al, 2020b). WOX1, 3 , and 5 promote auxin synthesis and ectopic YUC1 expression partially restores the leaf size, which links the WOX homeobox proteins and the hormone auxin in the context of controlling leaf growth (Zhang et al, 2020b). In addition, WOX1 and WOX3 genes are repressed by KAN and activated by MP (Nakata et al, 2012; Nakata and Okada, 2012; Caggiano et al, 2017).…”

Section: The Establishment and Maintenance Of Leaf Polaritymentioning

confidence: 99%

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From genes to networks: The genetic control of leaf development

Wang

Kong

Zhou

2021

JIPB

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Substantial diversity exists for both the size and shape of the leaf, the main photosynthetic organ of flowering plants. The two major forms of leaf are simple leaves, in which the leaf blade is undivided, and compound leaves, which comprise several leaflets. Leaves form at the shoot apical meristem from a group of undifferentiated cells, which first establish polarity, then grow and differentiate. Each of these processes is controlled by a combination of transcriptional regulators, microRNAs and phytohormones. The present review documents recent advances in our understanding of how these various factors modulate the development of both simple leaves (focusing mainly on the model plant Arabidopsis thaliana) and compound leaves (focusing mainly on the model legume species Medicago truncatula).

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Section: The Establishment and Maintenance Of Leaf Polaritymentioning

confidence: 99%

Section: The Establishment and Maintenance Of Leaf Polaritymentioning

confidence: 99%

Section: The Establishment and Maintenance Of Leaf Polaritymentioning

confidence: 99%

See 1 more Smart Citation

From genes to networks: The genetic control of leaf development

Wang

Kong

Zhou

2021

JIPB

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“…Heat maps are displayed on the second of two time points. Cells were assigned tissue identities using the cell distance process with filtering based on cell morphology, and these identities were exported as parent labels to calculate area extension in organ-aligned directions in each tissue (Zhang et al, 2020).Two replicate time-lapse series were acquired from fruit on different plants in a single experiment, and progression through developmental stages to explosion was compared with non-imaged fruit to show a negligible effect of imaging on fruit development.…”

Section: Confocal Laser Scanning Microscopy (Clsm)mentioning

confidence: 99%

INDEHISCENT regulates explosive seed dispersal

Galstyan

Sarchet

Campos-Martín

et al. 2021

Preprint

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How traits evolve to produce novelty or stasis is an open question in biology. We investigate this question in Cardamine hirsuta, a relative of Arabidopsis thaliana that employs explosive fracture to disperse its seeds. This trait evolved through key morphomechanical innovations that distinguish the otherwise very similar, dehiscent fruit of these two species. Using CRISPR/Cas9, we show that dehiscence zone formation is absolutely required for explosive fracture in C. hirsuta, and is controlled by the bHLH transcription factor INDEHISCENT (IND). Using mutant screens, we identified the MADS-box transcription factor FRUITFULL (FUL) as a negative regulator of IND in C. hirsuta. Although FUL function is conserved in C. hirsuta, the consequences of IND mis-expression differ in ful mutants of C. hirsuta versus A. thaliana. In ful mutants of both species, valve tissue is replaced by dehiscence zone tissue, which comprises two distinct cell types: lignified layer and separation layer cells. While A. thaliana ful mutants develop stunted fruit with ectopic lignified layer cells, C. hirsuta ful mutants have elongated fruit with ectopic separation layer cells. We show that IND dose determines the proportion of these two cell types in ectopic dehiscence zones. We also show that the extent of ectopic lignification caused by IND mis-expression determines fruit length. Our findings indicate developmental system drift in the conserved gene network patterning dehiscent fruit in two related Brassicaceae species.

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“…It has proven especially useful for the analysis of confocal microscopy images from time-lapse data in order to quantify the cellular level dynamics of growth, cell division and gene expression (e.g. Bringmann & Bergmann, 2017;Feng et al, 2018;Hervieux et al, 2016;Hong et al, 2016;Kierzkowski et al, 2019;Louveaux et al, 2016;Sapala et al, 2018;Scheuring et al, 2016;Tsugawa et al, 2017;Vlad et al, 2014;Zhang et al, 2020;Zhu et al, 2020). Key to the approach taken in the software is the representation of cell layers as curved, triangulated surface meshes that capture the overall 3D shape of organs, which retains much of the simplicity of 2D segmentation and lineage tracking.…”

Section: Introductionmentioning

confidence: 99%

MorphoGraphX 2.0: Providing context for biological image analysis with positional information

Strauss

Runions

Lane

et al. 2021

Preprint

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Positional information is a central concept in developmental biology. In developing organs, positional information can be idealized as a local coordinate system that arises from morphogen gradients controlled by organizers at key locations. This offers a plausible mechanism for the integration of the molecular networks operating in individual cells into the spatially-coordinated multicellular responses necessary for the organization of emergent forms. Understanding how positional cues guide morphogenesis requires the quantification of gene expression and growth dynamics in the context of their underlying coordinate systems. Here we present recent advances in the MorphoGraphX software (Barbier de Reuille et al. eLife 2015;4:e05864) that implement a generalized framework to annotate developing organs with local coordinate systems. These coordinate systems introduce an organ-centric spatial context to microscopy data, allowing gene expression and growth to be quantified and compared in the context of the positional information thought to control them.

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A WOX/Auxin Biosynthesis Module Controls Growth to Shape Leaf Form

Cited by 86 publications

References 56 publications

From genes to networks: The genetic control of leaf development

From genes to networks: The genetic control of leaf development

INDEHISCENT regulates explosive seed dispersal

MorphoGraphX 2.0: Providing context for biological image analysis with positional information

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