A Visible and Near-Infrared, Dual-Channel Fluorescence-On Probe for Selectively Tracking Mitochondrial Glutathione

Abstract

A naphthalimide-and cyanine-dressing fluorescent probe is utilized to specifically and selectively detect glutathione in both visible and near-infrared channels, respectively. Cell imaging indicates that this probe can target mitochondria and track intracellular glutathione in dual channels in a spatiotemporal and synchronous manner.

Aggregation-induced emission enhancement (AIEE)-active tetraphenylethene (TPE)-based chemosensor for Hg2+ with solvatochromism and cell imaging characteristics

“…Fluorescent probe is a powerful tool for optical imaging, which allows direct visualization of biological analytes. 53 Luminogen 1 was AIEE-active due to the restriction of intramolecular rotation in the aggregate state, which is benecial for cell imaging. Indeed, the viability of HeLa cells incubated with luminogen 1 was evaluated by the standard MTT method (Fig.…”

A Cofactor‐Substrate‐Based Supramolecular Fluorescent Probe for the Ultrafast Detection of Nitroreductase under Hypoxic Conditions

“…Further studies on intracellular catalytic kinetics [37,38] of NTR in MCF-7 cells with Zn-MPB'L-NO 2 , L-NO 2 ,o rL-NO 2 -DMPDD were conducted under hypoxic conditions (0.1 %O 2 )w ith different incubation times ( Figure 3B,C). Fluorescence images of cells were obtained in the red channel at 508-608 nm and l ex = 488 nm.…”

A Distinctive Spinach‐Based Carbon Nanomaterial with Chlorophyll‐Rich and Near‐Infrared Emission for Simultaneous In Vivo Biothiol Imaging and Dual‐Enhanced Photodynamic Therapy of Tumor

“…Among these small molecules, GSH is the biothiol with the highest intracellular level . The biothiol maintains redox balance in organisms, and aberrant in vivo biothiol levels are intimately associated with many diseases . Excessive biothiol can result in the occurrence of cancer, heart disease, and other major diseases, and can also accelerate aging .…”