A vesicating dermatitis from a blister beetle, in the neck of Septuagenarian Saudi male

Aboud, Khalid Al; Aboud, Daifullah Al; Aboud, Ahmad Al

doi:10.7241/ourd.20201.30

Cited by 6 publications

(8 citation statements)

References 2 publications

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“…In our study, the majority of patients were females presenting with cosmetic problems, which is consistent with other studies. 1,32 However, the effect of sex on morbidity has not been determined, as other studies have also reported a high morbidity rate in men. 33 The fact that women are more conscious of their appearance than men may explain the higher incidence in women in some studies.…”

Section: Discussionmentioning

confidence: 99%

Risk of Non-Alcoholic Fatty Liver Disease in Xanthelasma Palpebrarum

Chen¹,

Lin²,

Wu³

et al. 2021

JIR

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Background: Xanthelasma palpebrarum (XP) is a sign of hyperlipidemia and is closely linked to atherosclerosis. Since fatty liver shares similar risk factors with atherosclerosis, we hypothesized that patients with XP are also at risk of non-alcoholic fatty liver disease (NAFLD). Methods: In this retrospective cohort study, 37 patients with XP were compared with sexand age-matched controls undergoing general health examination. Moreover, demographic information and lipid profiles were compared. The risk of NAFLD was evaluated using the hepatic steatosis and ZJU indices. In addition, we analyzed publicly available RNA sequencing data from the GSE48452 and GSE61260 datasets in the Gene Expression Omnibus database. Findings: Patients with XP had higher scores of hepatic steatosis index (37 ± 1.13 vs 32 ± 0.82, p=0.0006) and ZJU index (38.77 ± 1.0 vs 33.88 ± 0.74, p=0.0002). In addition, they had higher levels of lipid parameters, including total cholesterol, low-density lipoprotein (LDL), and fasting glucose. Among patients with fatty liver, individuals presenting with XP showed higher serum levels of total cholesterol (216 ± 10.4 vs 188.9 ± 7.6, p=0.04), fasting glucose (117.1 ± 6.4 vs 98.3 ± 2.4, p=0.002), and low-density lipoprotein (145.1 ± 8.7 vs 115.6 ± 6.4, p=0.009) than those without XP. In gene expression analysis, individuals presenting with non-alcoholic steatohepatitis showed higher Z scores of xanthelasma than those without non-alcoholic steatohepatitis. Conclusion:Our results suggest that individuals with XP have a higher risk of progression to NAFLD and develop a more severe dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Risk of Non-Alcoholic Fatty Liver Disease in Xanthelasma Palpebrarum

Chen¹,

Lin²,

Wu³

et al. 2021

JIR

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“…GCPRs are nested in the GCX of the cell membrane, which binds extracellular substances and transmits signals to an intracellular molecule called a G protein (guanine nucleotide-binding protein) [176]. GCX disruption affects the GPCRs downstream signaling pathways and the enzymes associated with these downstream pathways are the targets of drug development [177]. These are epigenetics in nature and could be temporary, occur during a lifetime, or heritable [178].…”

Section: Drug Discovery Paradigmsmentioning

confidence: 99%

Curative and Preventive Treatment for Cardiovascular Disease (CVD) Targeting Multiple Etiology

Tunac¹

2021

CCR

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Gene deficient or knockout (KO) mice and rabbits are models of atherosclerosis focusing on cholesterol plaques, which do not reflect the complex etiology of cardiovascular disease (CVD). Inhibiting the 3-hydroxy-3-methyl-glutarylcoenzyme A (HMG-CoA) reductase or the proprotein convertase subtilisin/kexin type 9 (PCSK9) reduce cholesterol levels but not the rate of CVD. Moreover, the one-drug-one-gene paradigm particularly targeting any one of the G protein-coupled receptors (GPCRs), which represent the largest protein family encoded by the human genome, has at best produced palliative treatment. Vascular diseases including CVD are caused by extraneous (xeno) factors, which are of multifactorial etiology consisting of upstream and downstream phases. The upstream phase is the physical breach of the cells protective glycocalyx (GCX) shield by chemical and biological pollutants, resulting in a sequela of cell damages (plexic) that is manifested downstream in the form of diseases, herein called xenoplexic diseases. Xenoplexic disease is an etiologic description while chronic disease is symptom-centric. This study treated a natural mouse with extraneous agents, which produced plaques and plaque reduction was the end point to evaluate the curative and/or preventive treatment effect of the 3-component compound therapy. Histopathology monitored the presence of plaque, and a 4-panel biomarker, based on GCX disruption, was subsequently developed as a surrogate to monitor plaque formation. Of the several 3-NCE combos tested 4 combos were found to be preventive and curative of plaques indicating the effectiveness of a combo platform therapy. One combo is chosen as the lead candidate and hereby designated as Embotricin TM .

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“…Warts are common benign lesions caused by the human papillomavirus, which affect approximately 10% of the global population. 1 In high‐risk populations such as children or immunocompromised individuals, the prevalence may be as high as 20% percent. 1 Despite the expanding arsenal of wart therapies, recalcitrant verrucae are quite common not only in those with predisposing risk factors but also in many otherwise healthy persons.…”

Section: Introductionmentioning

confidence: 99%

Intralesional bleomycin for treatment of a recalcitrant wart in an immunocompromised patient: A safe, effective, and underutilized therapy

Ngo

Hwang

Amin

et al. 2022

Clinical Case Reports

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A vesicating dermatitis from a blister beetle, in the neck of Septuagenarian Saudi male

Abstract: A 72 years old Saudi male presented with an itchy and mildly painful skin lesion on the left side of the neck after being contacted before 2 days by a blister beetle while sleeping at night.

Cited by 6 publications

References 2 publications

Risk of Non-Alcoholic Fatty Liver Disease in Xanthelasma Palpebrarum

Risk of Non-Alcoholic Fatty Liver Disease in Xanthelasma Palpebrarum

Curative and Preventive Treatment for Cardiovascular Disease (CVD) Targeting Multiple Etiology

Intralesional bleomycin for treatment of a recalcitrant wart in an immunocompromised patient: A safe, effective, and underutilized therapy

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