A Validation Study of the Dementia Questionnaire

Abstract

To determine the validity of the Dementia Questionnaire (a semistructured informant interview) for the diagnosis of dementia.Design: Comparison of dementia status determined by a telephone-administered informant questionnaire with the criterion standard of clinical diagnosis established by examination and laboratory studies.

Validity of family history diagnosis for dementia

“…Thus, the relative lack of sensitivity of the family history in their work, in contrast to our and other studies Silverman et al, 1986Silverman et al, , 1989Kawas et al, 1994;Li et al, 1997] may, in part, be accounted for by overestimation of AD among relatives using the interview-based method. Cumulative incidences in first-degree relatives of probands with AD are generally under 2% by age 55 and by age 70 are under 5% [Silverman et al, 1994;Farrer et al, 1989;Breitner et al, 1988], more in line with rates obtained by their family history diagnosis.…”

Validity of family history diagnosis for dementia

“…Thus, the relative lack of sensitivity of the family history in their work, in contrast to our and other studies Silverman et al, 1986Silverman et al, , 1989Kawas et al, 1994;Li et al, 1997] may, in part, be accounted for by overestimation of AD among relatives using the interview-based method. Cumulative incidences in first-degree relatives of probands with AD are generally under 2% by age 55 and by age 70 are under 5% [Silverman et al, 1994;Farrer et al, 1989;Breitner et al, 1988], more in line with rates obtained by their family history diagnosis.…”

Familial Patterns of Risk in Very Late-Onset Alzheimer Disease

“…However, since most affected relatives are usually dead at the time of study (and many others may be otherwise unavailable), the usually desirable direct family study approach would fail to ascertain most relatives of greatest interest. Furthermore, studies of the family history method conducted here and by others have found good reliability 34,35 and good agreement with independently derived clinical assessments 40 and neuropathologically derived diagnoses. 41 Nevertheless, as the validity studies have dealt primarily with living or relatively recently deceased individuals, the validity of an AD classification in long-dead relatives remains uncertain.…”

The Israel Registry for Alzheimer’s Prevention (IRAP) Study: Design and Baseline Characteristics

“…FH-is defined as an offspring of a father who passed the age of 70 and a mother who passed the age of 75, who are currently (or were at time of death) cognitively normal. This control group definition is consistent with that of similar cohort studies, e.g., the Wisconsin Registry of Alzheimer's Prevention (WRAP) [47], the Adult Children Study [48], and other cohorts [49].…”

Validity of family history diagnosis for dementia

“…Thus, the relative lack of sensitivity of the family history in their work, in contrast to our and other studies Silverman et al, 1986Silverman et al, , 1989Kawas et al, 1994;Li et al, 1997] may, in part, be accounted for by overestimation of AD among relatives using the interview-based method. Cumulative incidences in first-degree relatives of probands with AD are generally under 2% by age 55 and by age 70 are under 5% [Silverman et al, 1994;Farrer et al, 1989;Breitner et al, 1988], more in line with rates obtained by their family history diagnosis.…”

Familial Patterns of Risk in Very Late-Onset Alzheimer Disease

“…However, since most affected relatives are usually dead at the time of study (and many others may be otherwise unavailable), the usually desirable direct family study approach would fail to ascertain most relatives of greatest interest. Furthermore, studies of the family history method conducted here and by others have found good reliability 34,35 and good agreement with independently derived clinical assessments 40 and neuropathologically derived diagnoses. 41 Nevertheless, as the validity studies have dealt primarily with living or relatively recently deceased individuals, the validity of an AD classification in long-dead relatives remains uncertain.…”

The Israel Registry for Alzheimer’s Prevention (IRAP) Study: Design and Baseline Characteristics

“…FH-is defined as an offspring of a father who passed the age of 70 and a mother who passed the age of 75, who are currently (or were at time of death) cognitively normal. This control group definition is consistent with that of similar cohort studies, e.g., the Wisconsin Registry of Alzheimer's Prevention (WRAP) [47], the Adult Children Study [48], and other cohorts [49].…”

Validity of family history diagnosis for dementia

“…Thus, the relative lack of sensitivity of the family history in their work, in contrast to our and other studies Silverman et al, 1986Silverman et al, , 1989Kawas et al, 1994;Li et al, 1997] may, in part, be accounted for by overestimation of AD among relatives using the interview-based method. Cumulative incidences in first-degree relatives of probands with AD are generally under 2% by age 55 and by age 70 are under 5% [Silverman et al, 1994;Farrer et al, 1989;Breitner et al, 1988], more in line with rates obtained by their family history diagnosis.…”

Familial Patterns of Risk in Very Late-Onset Alzheimer Disease

“…However, since most affected relatives are usually dead at the time of study (and many others may be otherwise unavailable), the usually desirable direct family study approach would fail to ascertain most relatives of greatest interest. Furthermore, studies of the family history method conducted here and by others have found good reliability 34,35 and good agreement with independently derived clinical assessments 40 and neuropathologically derived diagnoses. 41 Nevertheless, as the validity studies have dealt primarily with living or relatively recently deceased individuals, the validity of an AD classification in long-dead relatives remains uncertain.…”

The Israel Registry for Alzheimer’s Prevention (IRAP) Study: Design and Baseline Characteristics

“…FH-is defined as an offspring of a father who passed the age of 70 and a mother who passed the age of 75, who are currently (or were at time of death) cognitively normal. This control group definition is consistent with that of similar cohort studies, e.g., the Wisconsin Registry of Alzheimer's Prevention (WRAP) [47], the Adult Children Study [48], and other cohorts [49].…”