A unique case of collagenous colitis presenting as protein-losing enteropathy successfully treated with prednisolone

Sano, Soichi; Yamagami, Keiko; Tanaka, Ayako; Nishio, Minako; Nakamura, Tomoyuki; Kubo, Yuki; Inoue, Takeshi; Ueda, Wataru; Okawa, Kenji; Yoshioka, Katsunobu

doi:10.3748/wjg.14.6083

Cited by 11 publications

(11 citation statements)

References 13 publications

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“…Association of protein‐losing enteropathy is generally acknowledged to be rare, and we could not find any studies on the actual frequency. In some case reports, protein leakage from the colon was identified by Technetium‐99m human serum albumin scintigraphy . With the same method, we were able to prove the existence of protein‐losing enteropathy in this case.…”

Section: Discussionmentioning

confidence: 57%

Acute onset collagenous colitis associated with protein‐losing enteropathy

Nakaya

Hosokawa

Kataoka

et al. 2017

J of Gen and Family Med

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Collagenous colitis is a cause of chronic diarrhea. We report an atypical case of collagenous colitis, presenting with an acute onset, and associated with protein‐losing enteropathy. An 82‐year‐old woman was admitted with a 1 week history of nausea, appetite loss, and diarrhea. Serum albumin level was low. Protein leakage from the small intestine was found by a Technetium‐99m human serum albumin scintigraphy. We diagnosed the patient with collagenous colitis from pathology findings of multiple biopsies taken from the colon. This case implies that collagenous colitis should be considered in acute watery diarrhea, and that it can cause protein‐losing enteropathy.

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Section: Discussionmentioning

confidence: 57%

Acute onset collagenous colitis associated with protein‐losing enteropathy

Nakaya

Hosokawa

Kataoka

et al. 2017

J of Gen and Family Med

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“…There is only one reported case in the literature of a 15-month-old with collagenous gastroduodenocolitis who presented with profound diarrhea, anemia, and low albumin [15]. In adults, only 2 cases of CC associated with PLE have been reported [16,17]. PLE was not part of the clinical presentations in those adult patients who had gastric or small intestinal involvement with CC [6,7].…”

Section: Discussionmentioning

confidence: 99%

“…PLE was not part of the clinical presentations in those adult patients who had gastric or small intestinal involvement with CC [6,7]. The exact mechanism of gastrointestinal protein loss in this condition is unknown, but abnormalities in the surface epithelium, superficial capillaries, and pericryptal fibroblast have been hypothesized [17]. Corticosteroids, budesonide, and 5-ASA have been all successfully used in the treatment of collagenous inflammatory mucosal disease [8].…”

Section: Discussionmentioning

confidence: 99%

Collagenous colitis associated with protein losing enteropathy in a toddler

Almadhoun¹

2017

J Gastrointest Dig Syst

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Collagenous mucosal inflammatory disease is a rare gastrointestinal disorder that involves the columnar lining of gastric and intestinal mucosa and is characterized by a distinct subepithelial collagen deposition. Recent clinical and pathological evidence have indicated that collagenous mucosal inflammatory disease can be extensive disease that may concomitantly involve several gastrointestinal sites at the same time. This entity, however, occurs infrequently in children. It is even less common to find concomitant depositions of collagen in the mucosa of gastrointestinal sites other than the colon. Only two cases in pediatric literature reported concomitant involvement, one with gastric and colonic involvement and the other one with gastroduodenocolitis. We are reporting a 15-month-old boy who presented with severe diarrhea and diffuse edema secondary to hypoalbuminemia. Further testing documented protein losing enteropathy (PLE) associated with collagenous colitis.

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“…Though the literature is limited to case reports, case series, and case-control studies, PPIs-related injuries should at least be considered when encountering a microscopic injury pattern, since PPIs withdrawal can be curative. While the endoscopic appearance is normal in microscopic colitis, a subset of PPIs-related colitis may present with linear mucosal defects,77–81 friability, bleeding,78 82 and a decreased vascular pattern 82. PPIs injury is more strongly linked to collagenous colitis than lymphocytic colitis 83…”

Section: Colonmentioning

confidence: 99%

Message in a bottle: decoding medication injury patterns in the gastrointestinal tract

et al. 2014

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Medication injury in the gastrointestinal tract (GIT) is a rapidly evolving topic. Increasing endoscopy together with an ageing population, polypharmacy, and a burgeoning drug industry offer heightened opportunities to observe the unintended side effects of therapeutic ingestants. In this review, we emphasise the most commonly encountered medication injuries involving the GIT, as well as emerging agents and mimics. While topics are organised by organ system, the reader should keep in mind that injury patterns are generally not site-specific. As such, awareness of these major morphologic patterns can be translated to multiple tissue sites to more broadly facilitate the diagnostic process.

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A unique case of collagenous colitis presenting as protein-losing enteropathy successfully treated with prednisolone

Cited by 11 publications

References 13 publications

Acute onset collagenous colitis associated with protein‐losing enteropathy

Acute onset collagenous colitis associated with protein‐losing enteropathy

Collagenous colitis associated with protein losing enteropathy in a toddler

Message in a bottle: decoding medication injury patterns in the gastrointestinal tract

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