A unified genotypic classification of infectious bursal disease virus based on both genome segments

Islam, Mohammad Rafiqul; Nooruzzaman, Mohammed; Rahman, Tazinur; Mumu, Tanjin Tamanna; Rahman, Mohammad Mijanur; Chowdhury, Emdadul Haque; Eterradossi, Nicolas; Müller, Hermann

doi:10.1080/03079457.2021.1873245

Cited by 47 publications

(92 citation statements)

References 78 publications

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“…The HLJ0504-like IBDVs (A3B3) are the main prevalent strains with high pathogenicity, which have been threatening the poultry farming in China for nearly 30 years [ 9 , 10 , 11 , 12 ]. Such type of IBDVs have also been circulating in the neighboring countries including Pakistan [ 11 , 14 ], India [ 15 ], Bangladesh [ 38 ], Thailand, Vietnam [ 39 ], and Korea [ 18 ], and were also reported in Venezuela [ 30 ]. Recently, the widespread of nVarIBDV (A2dB1) was discovered in China [ 16 , 40 ] and also reported in Japan [ 17 ], Korea [ 18 ], and Malaysia [ 19 ] in succession.…”

Section: Discussionmentioning

confidence: 99%

Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Wang

Jiang

Fan

et al. 2021

Viruses

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Infectious bursal disease virus (IBDV) is a non-enveloped, bi-segmented double-stranded RNA virus and the causative agent of a poultry immunosuppressive disease known as infectious bursal disease (IBD). The novel variant IBDV (nVarIBDV) recently posed a great threat to the development of the poultry industry. In this study, we identified a novel segment-reassortant IBDV strain, IBDV-JS19-14701 (Genotype A2dB3). Phylogenic analysis showed that Segments A and B of IBDV-JS19-14701 were derived from emerging nVarIBDV (Genotype A2dB1) and long-prevalent HLJ0504-like strains (Genotype A3B3) in China, respectively. The pathogenicity of IBDV-JS19-14701 was further evaluated via animal experiments. IBDV-JS19-14701 exhibited a similar virulence to chickens with the nVarIBDV. The identification of this reassortment event is beneficial for understanding the epidemiology of nVarIBDV and will contribute to the efficient prevention and control of IBD.

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Section: Discussionmentioning

confidence: 99%

Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Wang

Jiang

Fan

et al. 2021

Viruses

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“…Regarding the vvIBDV, previous epidemiological data have revealed that the highly lethal HLJ0504-like strain (A3B3 genotype) has, for long, been a major epidemic strain in China ( 21 ). Moreover, this strain has been reported worldwide in Pakistan ( 22 ), India ( 23 ), Bangladesh ( 24 ), Thailand ( 24 ), Vietnam ( 25 ), South Korea ( 13 ), Venezuela ( 26 ), and Nigeria ( 27 ). The findings of the present study have confirmed that the A3B3 genotype strain remains prevalent throughout China.…”

Section: Discussionmentioning

confidence: 99%

Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020

et al. 2021

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Infectious bursal disease (IBD) is an acute and highly contagious immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which seriously threatens the healthy development of the poultry industry. Since its spread to China in the early 1990s, the very virulent IBDV (vvIBDV) characterized by high lethality, has been the focus of prevention and control. However, the novel variant IBDV (nVarIBDV), which has been widely prevalent in China since 2017, has brought a new threat to the poultry industry. In this study, the prevalence of IBDV in the important poultry-raising areas of China from 2019 to 2020 was detected. Of these, 45.1% (101/224) of the samples and 61.9% (26/42) of the chicken flocks were shown to be positive for IBDV. For 50 IBDVs, the sequences of the hypervariable region of the VP2 gene in segment A and of the B-marker of the VP1 gene in segment B were analyzed. The results revealed the coexistence of a number of different IBDV genotypes, including A2dB1 (nVar, 26/50, 52.0%), A3B3 (HLJ0504-like, 15/50, 30.0%), A1B1 (classical, 1/50, 2.0%), and A8B1 (attenuated, 1/50, 2.0%). This indicated that the newly emerging nVarIBDV of A2dB1 and the persistently circulating HLJ0504-like vvIBDV of A3B3 are the two important epidemic strains. Furthermore, we established that segment reassortment has occurred among these circulating strains. This study is the first to reveal the novel epidemic characteristics of IBDV since the report of the emerging nVarIBDV of A2dB1 in China.

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“…All cloacal swabs from the layer farms tested negative for IBDV, whereas 3 out of 8 bursa imprint pools from the broiler farm (1/16 farms, 6.25%) were positive for IBDV, resulting in highly similar sequences (99.8–100% identity) to the Winterfield-2512 vaccine strain (reference strain MH329181.1), belonging to the classical/virulent genogroup A1a [ 34 ] ( Figure 3 ). According to the declared vaccination strategy of the farm, this strain was used for the bird immunizations.…”

Section: Resultsmentioning

confidence: 99%

“…Nucleotide sequences were initially evaluated for specificity using a BLAST [ 32 ] search in order to be characterized. For phylogenetic analyses, the database proposed by Valastro et al, (2016) was used for IBV characterization; for IBDV strain characterization, the adopted reference database and classification were those published by Islam et al, (2021); then, for NDV classification, the latest and updated classification approach by Dimitrov et al, (2019) was used [ 33 , 34 , 35 ]. Sequences were aligned to reference datasets using the MEGA X [ 36 ] software for phylogenetic analyses.…”

Section: Methodsmentioning

confidence: 99%

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Molecular Survey of Viral Poultry Diseases with an Indirect Public Health Significance in Central Ethiopia

Wayou

Kassa

Pasotto

et al. 2021

Animals

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The importance of poultry production is globally increasing, in Ethiopia as well, where high-quality protein and contained costs make poultry a valuable food resource. However, this entails some problems linked to rural, backyard and intensively reared flock proximity and pathogen circulation. This study is aimed at monitoring the presence of important viral pathogens in poultry (infectious bronchitis virus (IBV), avian metapneumovirus (aMPV), infectious bursal disease virus (IBDV) and Newcastle disease virus (NDV)) in Ethiopia. Respiratory and cloacal swabs and bursa of Fabricius and kidney imprints on FTA cards were collected in 2021 from 16 farms and tested for IBV, aMPV, NDV and IBDV. One farm was positive for IBDV, resulting in strains similar to those present in vaccines, belonging to genogroup A1a; two farms were positive for IBV but, due to sensitivity limits, only one sample was sequenced, resulting in a 4/91-like strain (GI-13); a layer farm tested positive for NDV with a Lasota-like vaccine strain. These findings suggest a low presence of these pathogens, probably due to the implementation of vaccination strategies, which is also testified by the detection of vaccine strains. A close diagnostic activity should be implemented on a routine basis in order to monitor pathogen circulation, ameliorate biosecurity measures and protect animal health and production levels.

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A unified genotypic classification of infectious bursal disease virus based on both genome segments

Cited by 47 publications

References 78 publications

Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

Genotyping and Molecular Characterization of Infectious Bursal Disease Virus Identified in Important Poultry-Raising Areas of China During 2019 and 2020

Molecular Survey of Viral Poultry Diseases with an Indirect Public Health Significance in Central Ethiopia

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