A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation

A survey of cyclic and linear siloxanes in indoor dust and their implications for human exposures in twelve countries

“…Several studies have reported toxicity, especially reproductive and endocrine effects, of siloxanes in laboratory animals (Burns-Naas et al, 1998;Burn-Naas et al, 2002;McKim et al, 2001;He et al, 2003;Meeks et al, 2007;Quinn et al, 2007a,b;Siddiqui et al, 2007). A risk assessment conducted in Canada indicated that D5 met the criteria for persistence (Environment Canada, 2011).…”

Volatile Methyl Siloxanes as Potential Hazardous Air Pollutants

“…The greatest number of data have been published on the toxicity of D4, which puts people at risk primarily due to the use of cosmetic products. It is considered to have toxic effects on reproductive processes [38][39][40][41], as well as the liver and lungs [42]. The effect of D4 on the estrous cycle of rats and mice also has been found [18,43,44].…”

The potential of methylsiloxanes as solvents for synthetic chemistry applications

“…Three of the analysed VMSs (MD 3 M, D 4 and D 5 ) present some health risks of comparable magnitude to some of the traditional organic solvents included in the assessment, although these are less than those of the non-polar solvents for which the VMSs are likely replacements (see below). Whereas MD 3 M and D 5 are irritants, D 4 is believed to impair fertility [35][36][37] and to exhibit estrogenic behaviour in rats and mice (see, for example, refs. 38, 39) The remaining VMSs have no associated health risks according to this particular methodology.…”

“…[40][41][42][43][44][45][46][47] and as a result their environmental impacts are widely recognised. 37 A Canadian study, has for example, concluded that D5 meets some toxicity and persistence criteria but not its bioacculuation criterion 48 while a recent update of the Equilibrium Criterion…”