“…This application introduces an innovative approach for the development of therapeutic interventions targeting virus detection and inhibition of viral infections. 143 Figure 10 Applications of 1,3-diene-based AIEgens in and biosensors, bioimaging, and PDT (A) The structure of HPB-X. Reproduced with permission from ref.…”
Section: Applications Of 13-diene-based Aiegensmentioning
confidence: 99%
“…Reproduced with permission from ref. 143 Copyright 2021 Elsevier. (B) Fluorescence response of HPB-I, HPB-P, HPB-C and HPB-B (1.0 × 10 −6 mol/L in DMSO/H 2 O mixture: 1/9999 v/v) upon the addition of different proteins (2.50 μg/mL).…”
Section: Applications Of 13-diene-based Aiegensmentioning
confidence: 99%
“…Reproduced with permission from ref. 143 Copyright 2021 Elsevier. (C) the mechanism of the turn-on detection of H5 by HPB-I.…”
Section: Applications Of 13-diene-based Aiegensmentioning
confidence: 99%
“…Reproduced with permission from ref. 143 Copyright 2021 Elsevier. (D) The synthesis route of TABD-Py-PF6.…”
Section: Applications Of 13-diene-based Aiegensmentioning
“…This application introduces an innovative approach for the development of therapeutic interventions targeting virus detection and inhibition of viral infections. 143 Figure 10 Applications of 1,3-diene-based AIEgens in and biosensors, bioimaging, and PDT (A) The structure of HPB-X. Reproduced with permission from ref.…”
Section: Applications Of 13-diene-based Aiegensmentioning
confidence: 99%
“…Reproduced with permission from ref. 143 Copyright 2021 Elsevier. (B) Fluorescence response of HPB-I, HPB-P, HPB-C and HPB-B (1.0 × 10 −6 mol/L in DMSO/H 2 O mixture: 1/9999 v/v) upon the addition of different proteins (2.50 μg/mL).…”
Section: Applications Of 13-diene-based Aiegensmentioning
confidence: 99%
“…Reproduced with permission from ref. 143 Copyright 2021 Elsevier. (C) the mechanism of the turn-on detection of H5 by HPB-I.…”
Section: Applications Of 13-diene-based Aiegensmentioning
confidence: 99%
“…Reproduced with permission from ref. 143 Copyright 2021 Elsevier. (D) The synthesis route of TABD-Py-PF6.…”
Section: Applications Of 13-diene-based Aiegensmentioning
“…[1][2][3][4] Due to their high sensitivity and selectivity, AIEbased luminogens (AIEgens) have gained considerable attention in applications such as detection and biological imaging. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Recently, several types of AIEgens, mainly including siloles, 21 pyroles, 22 tetraphenylethylenes, [23][24][25] pyrazines, 26 triphenylamines, 27 naphthalenes, 28 and tetraphenyl-1,3-butadiene, 29 have been successfully developed. Experimental studies and theoretical calculations consistently indicate that the restriction of intramolecular motion (RIM) serves as the primary mechanism underlying the AIE effect.…”
Anion-π+ interaction as an important type of non-covalent interaction has great potential in the construction of aggregation-induced emission (AIE) molecules. In this work, tetraphenylimidazole (PI) and diphenylphenanthroimidazole (PPI) were used...
Surgical resection is the preferred option for hepatocellular carcinoma (HCC), but surgical navigation technology using indocyanine green still has some drawbacks such as non‐specific imaging, thus it is very important to develop new fluorescence imaging technology. All‐cis hexaphenyl‐1,3‐butadiene derivative (ZZ‐HPB‐NC) with aggregation‐induced emission (AIE) feature has been reported to be quickly turned‐on fluorescent response in the intraoperative frozen‐section slides of HCC. However, the probe did not respond to normal liver tissue around HCC. In order to enhance the diagnostic rate and elucidate the response mechanism, all‐trans configuration EE‐HPB‐NC, was furtherly synthesized. Within two minutes, non‐cancer tissues could be fluorescently labeled by EE‐HPB‐NC by spraying, showing the same effect with ZZ‐HPB‐NC to HCC. The results indicated that the configuration‐induced cross‐identification fluorescence imaging strategy was achieved through the combination of ZZ‐ and EE‐HPB‐NC. Then the mechanism of HPB‐NC localization in HCC lesions was explored, and the binding of HPB‐NC with specific proteins in cells resulted in the AIE effect to label HCC cells. On this basis, the accuracy of specific fluorescence imaging for HCC was further verified on the mouse hepatic neoplasm models, indicating that it has clinical application potential for surgical fluorescence real‐time navigation.
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