A triple-stimuli responsive hormone delivery system equipped with pillararene magnetic nanovalves

Li, Xiangshuai; Han, Junyou; Wang, Xin; Zhang, Yanxin; Chen, Jia; Qin, Jianchun; Wang, Qianqian; Wu, Jia‐Rui; Fang, Wen‐Hui; Yang, Ying‐Wei

doi:10.1039/c8qm00509e

Cited by 73 publications

(58 citation statements)

References 55 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Incorporation of MSNs into the gated nanodevices not only endows the therapeutic platform with an enhanced permeability and retention effect, but also provides considerable potential for anchoring versatile functionalities as caps owing to their tunable particle size and switchable pore entrances. [59][60][61][62][63][64][65] Nowadays, light provides many superiorities as a stimulus, depending on the easy operation spatially and temporally, remote responsiveness, and controllable properties, among which near-infrared (NIR) light is regarded as a superior alternative due to the deep tissue penetration and noninvasiveness. Photochemical pulses have proved to be an effective method for on-demand drug release based on the various photochemical mechanisms, including photoisomerization, photolysis, and photocleavage.…”

Section: Msn Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

“…Recently, we have applied a new magnetic nanovalve system in promoting the growth of plants, such as Arabidopsis thaliana and cabbages ( Figure 4). 65 We installed gated components comprising water-soluble carboxylatopillar [5]arene ammonium pillar [5]arene (WP[5]A) modified Fe 3 O 4 NPs (WP [5]A-Fe 3 O 4 ) on hollow MSNs (HMSNs) with larger capacity to load gibberellic acid (GA3) as plant hormones. This multifunctional delivery system displayed bidirectional pH-responsive release since the cargo could be released under both acidic and alkaline conditions.…”

Section: Msn Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

Song

Yang

2019

Matter

Self Cite

168

117

View full text Add to dashboard Cite

From motor proteins to molecular machines, supramolecular chemistry has been revealed as a remarkable link to bridge the gap between biology, chemistry, and materials. Taking inspiration from the dynamic, reversible, and directional manner of non-covalent interactions that can respond to diversiform external stimuli, supramolecular nanovalves installed on the surface of inorganic or hybrid nanocarriers have received extensive attention in stimuli-responsive delivery of small drug molecules, implying their outspread bioapplications in cancer/gene therapy, biomedical application, and antimicrobial regulations. The state of supramolecular nanovalves could be well regulated by switching the conformation or the assembled/disassembled state of the assemblies. This tutorial review lays the foundation for a better understanding of the significant and typical intelligent drug-delivery systems immobilized with supramolecular polymers or supramolecular pseudorotaxanes as the gating entities of nanovalvebased molecular machines, by showing their chemical structures, operation modes, and release modalities triggered by various actuations at molecular scale. In particular, relevant perspectives of supramolecular therapeutics will also be elaborated upon.

show abstract

Section: Msn Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Section: Msn Nanocarriers For Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

Song

Yang

2019

Matter

Self Cite

168

117

View full text Add to dashboard Cite

show abstract

“…Reproduced with permission. [65] Copyright 2019, Royal Society of Chemistry. a biomimetic potassiumtransporting nanochannel fabricated from poly(ethylene terephthalate) (PET) gated by supramolec ular switches based on the host−guest complexation of mercap toacetic acid pillar [5]arene (MAP5) and HDA for the inhibition of mercury poisoning ( Figure 9D).…”

Section: D Nanosurfacesmentioning

confidence: 99%

Pillar[n]arene‐Based Supramolecular Switches in Solution and on Surfaces

Lou

Yang

2020

Advanced Materials

Self Cite

View full text Add to dashboard Cite

response to specific physical or chemical stimuli including, but not limited to, pH, light, redox, competitive agents, and tem perature. In particular, pseudorotaxanes, comprising of a rod component without bulky end groups encircled by a wheel entity via noncovalent bonds, can be employed as a superior class of candidates for supramolecular switches. [3] There fore, the study of macrocyclic receptors as the wheel entity of pseudorotaxanes has become one of the research hotspots in the field and received great attention. [4] Following the advance of macrocyclic chemistry based on crown ethers, cyclo dextrins, calixarenes, and cucurbit[n]urils, pillar[n]arenes (n = 5-15), first reported by Ogoshi et al. in 2008, have emerged as a rising star among synthesized macro cycles. [5] Pillar[n]arenes, composed of n hydroquinone units linked by methylene bridges at the 2 and 5positions, pos sess rigid pillarlike molecular structures and πelectron rich hydrophobic cavities that are favorable for the binding of electrondeficient guests. [6] Owing to the highly modi fiable rims of pillar[n]arenes, numerous pillar[n]arene derivatives with diverse functionalities can be facilely obtained either via the cyclization of pretailored 1,4dialkoxybenzene monomers or by postsynthetic modification. [7] The versatile functionalization of pillar[n]arenes beneficially affords their pos sible usages in both organic and aqueous phases, making the host−guest interactions with a large variety of ionic or neutral guests possible. [8] Thus far, pillar[n]arenes and their deriva tives have served as a prominent family of building blocks for the rational creation of supramolecular switches on the basis of the formation of various pseudorotaxanes upon their respon sive complexation with guest entities. [3] Although the dynamic activities of supramolecular switches are generally and fundamentally investigated in solution, growing interest has been focused on the transfer of supra molecular switches from solution phase to more condensed phases, that is, solid surfaces and interfaces. Through the incor poration on rigid solid supports of metal or other inorganic surfaces, the installed switches are able to produce amplified collective switching motions, concurrently modulating the sur face properties and endowing the inherent substrates with valid responses to specific triggers. [2a,9] Hence, the shifting of supra molecular switches from solution to solid surfaces denotes a significant step toward the realization of artificial nanosystems with operationally controllable properties, stimuliresponsive features, and multifunctionalities. The design and synthesis of new synthetic macrocycles has driven the rapid development of supramolecular chemistry and materials. Pillar[n]arenes, as a new type of macrocyclic compounds, are used as a promising type of building blocks for switchable supramolecular systems due to their versatile functionalization and the ability of binding toward various guest molecules. A number of guests can form inclusion complexes with...

show abstract

“…32 Thus, anionic and cationic watersoluble pillar[n]arenes have been widely explored as hosts for chemotherapeutic drugs 33,34 as well as micelles, 35,36 vesicles, [36][37][38][39][40][41] and gatekeepers in nanovalve systems. [42][43][44][45][46][47] To the best of our knowledge, the combination of watersoluble carboxylate-substituted pillar [5]arene (CP [5]A) grafted onto SPIONs as an AMF stimuli-responsive nanodevice for drug delivery has not been described in the literature. Magnetite coated with CP [5]A has been reported for environmental applications, such as dye separation, 48 pesticide detection in beverages, 49 and used as gatekeepers in nanovalves for hormone delivery to plants.…”

Section: Introductionmentioning

confidence: 99%

“…Magnetite coated with CP [5]A has been reported for environmental applications, such as dye separation, 48 pesticide detection in beverages, 49 and used as gatekeepers in nanovalves for hormone delivery to plants. 47 For biomedical applications, SPIONs coated with metalorganic frameworks (MOFs) have been used as reservoir for fluorouracil (an anticancer drug), gated with carboxylatesubstituted pillar [6]arene (CP[6]A) and investigated as a theranostic nanoplatform. 50 Therefore, our goal in this work is to develop a novel chemo-hyperthermia nanodevice based on watersoluble carboxylate-substituted pillar [5]arene CP [5]A and SPIONs, namely MNP-CP [5]A (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin

Fernandes¹,

Santos²,

Madriaga³

et al. 2019

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

An alternating magnetic field (AMF)-stimuli responsive nanodevice based on magnetic nanoparticles (MNP) functionalized with water-soluble carboxylate-substituted pillar[5]arene (CP[5]A), namely MNP-CP[5]A, as a multiplatform for cancer treatment has been designed. MNP-CP[5]A was loaded with doxorubicin (DOX), showing a loading capacity of 9.5 mg g-1. The nanodevice demonstrated good colloidal stability, superparamagnetic behavior, and was capable to generate detectable heat in solution induced by AMF application. DOX release, monitored by ultraviolet-visible (UV-Vis) spectroscopy, was investigated by varying the temperature (37 and 45 °C) without AMF and in the presence of AMF (frequency (f) = 307 kHz, field amplitude (H) = 200 Oe, 45 °C) at pH = 7.4. Thermo-induced DOX release without AMF was 1.9% (1.8 μg mL-1) and 2.3% (3.3 μg mL-1) at 37, and 45 °C within 50 min, respectively. In an AMF DOX release increased to 5.7% (8.2 μg mL-1) within 50 min. Therefore, MNP-CP[5]A-DOX works as a chemo-hyperthermia nanodevice.

show abstract

A triple-stimuli responsive hormone delivery system equipped with pillararene magnetic nanovalves

Abstract: A stimuli responsive hormone delivery system was designed and constructed from mesoporous silica and pillararene magnetic nanovalves, which can release hormones on command to promote the growth of Arabidopsis thaliana and cabbage.

Cited by 73 publications

References 55 publications

Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

Stimuli-Responsive Drug-Delivery Systems Based on Supramolecular Nanovalves

Pillar[n]arene‐Based Supramolecular Switches in Solution and on Surfaces

A Self-Assembled AMF-Responsive Nanoplatform Based on Pillar[5]arene and Superparamagnetic Nanoparticles for Controlled Release of Doxorubicin

Contact Info

Product

Resources

About