A Trial of Antiparasitic Treatment to Reduce the Rate of Seizures Due to Cerebral Cysticercosis

Garcı́a, Héctor H.; Pretell, E. Javier; Gilman, Robert H.; Martínez, Santiago; Moulton, Lawrence H.; Brutto, Oscar H. Del; Herrera, Genaro; Evans, Carlton A.; González, Armando E.

doi:10.1056/nejmoa031294

Cited by 366 publications

(324 citation statements)

References 33 publications

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“…A clinical trial regarding treatment with cysticidal drugs for patients with epilepsy due to NC did not fi nd a reduction in the number of seizures overall but did report a reduction in the number of generalized seizures in patients treated with albendazole [30] Interpreting the risk of seizures after NC is diffi cult because of the failure to distinguish acute symptomatic seizures from epilepsy. These diffi culties are increased in patients who have mixed forms, including active, transitional, and calcifi ed lesions.…”

Section: Prognosis For Seizure Recurrence In Patients With Neurocystimentioning

confidence: 99%

Epilepsy in the developing world

Carpio

Hauser²

2009

Curr Neurol Neurosci Rep

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Section: Prognosis For Seizure Recurrence In Patients With Neurocystimentioning

confidence: 99%

Epilepsy in the developing world

Carpio

Hauser²

2009

Curr Neurol Neurosci Rep

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“…[1][2][3][4][5] The T. solium life cycle includes the pig as an intermediate host, having larval cysts ( Cysticercus cellulosae ), and the human as the definitive host, developing adult tapeworms (taeniasis) after consumption of viable cysts. Humans also act as intermediate hosts (cysticercosis) when they consume tapeworm eggs, which then may lead to neurocysticercosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Efficacy of Teaching Methods Regarding Prevention of Human Epilepsy Caused by Taenia solium Neurocysticercosis in Western Kenya

Wohlgemut

Dewey²,

Levy³

et al. 2010

The American Journal of Tropical Medicine and Hygiene

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Abstract. Taenia solium neurocysticercosis is a major cause of adult-onset epilepsy in developing countries. A questionnaire was administered to 282 Kenyan farmers, followed by a workshop, a second questionnaire, one-on-one training, and a third questionnaire. People who attended workshops were more likely to know how T. solium causes epilepsy in humans in the third visit than the second ( P = 0.001). The likelihood that farmers would tether their pigs 100% of the time, limiting exposure to tapeworm eggs, increased after the first ( P < 0.001) and second visits ( P < 0.001). Farmers were more likely to have heard of Cysticercus cellulosae in the second ( P = 0.001) and third visits ( P = 0.007), and to know how pigs acquire infection in the second ( P = 0.03) and third visits ( P = 0.003). Farmers with at least a grade 8 education were more likely to know how T. solium is transmitted to humans in the second ( P = 0.001) and third visits ( P = 0.009), and were more likely to understand the relationship between epilepsy and T. solium in the second ( P = 0.03) and third visits ( P = 0.03). Grade 8 education may enhance learning from written material. Workshops followed by individual on-farm training enhanced knowledge acquisition and behavior changes. Training local government extension workers contributed to the sustainability of this project.

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“…In a double-blind, placebo-controlled study of patients with seizures resulting from viable parenchymal cysts, antiparasitic drugs decreased the burden of parasites and was effective in reducing the number of generalized seizure 8) . In our case, we used a praziquantel for 2 weeks after the operation to eradicate other possible systemic involvements.…”

Section: Discussionmentioning

confidence: 99%

Neurocysticercosis Involving the Pituitary Stalk : Case Report and Literature Review

Cheong

Kim

2010

J Korean Neurosurg Soc

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J Korean Neurosurg Soc 48 : [91][92][93] 2010 Neurocysticercosis (NCC) is the most common parasitic infestation of the central nervous system. Most cases of NCC are to related and/or associated with inflammation within the cerebral parenchyma. A 71-year-old woman presented with a 4-year history of visual disturbance. This symptom had become aggravated 4 weeks earlier. Her visual acuity gradually decreased and superior hemianopsia was noted. Magnetic resonance imaging (MRI) revealed an enhanced and thickened pituitary stalk accompanying a suspicious mass. The provisional diagnoses were lymphoma, glioma, or other inflammatory conditions. Laboratory studies, including blood and hormonal studies, showed normal findings. Surgical resection was performed. In the pathological examination, degenerated parasitic wall structure was seen and its contents were composed of completely degenerated focal globular structures suggesting the scolex of cysticercus. We report an unusual case of NCC involving the pituitary stalk which was presented with a juxtasellar tumor. The possible underlying mechanisms are discussed with a review of pertinent literature.

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A Trial of Antiparasitic Treatment to Reduce the Rate of Seizures Due to Cerebral Cysticercosis

Cited by 366 publications

References 33 publications

Epilepsy in the developing world

Epilepsy in the developing world

Evaluating the Efficacy of Teaching Methods Regarding Prevention of Human Epilepsy Caused by Taenia solium Neurocysticercosis in Western Kenya

Neurocysticercosis Involving the Pituitary Stalk : Case Report and Literature Review

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