Biochemical Pharmacology volume 80, issue 4, P540-547 2010 DOI: 10.1016/j.bcp.2010.04.037 View full text
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Kaname Ohyama, Mari Tomonari, Tomoko Ichibangase, Hideto To, Naoya Kishikawa, Kenichiro Nakashima, Kazuhiro Imai, Naotaka Kuroda

Abstract: Abstract Studies s uggest t hat pr e-administration o f d ocetaxel ( DOC) in a driamycin ( ADR)-analysis o f h eart t issue from control, intermittent-dosing (DOC-ADR), and s imultaneous -dosing (ADR&DOC) groups. In DOC-ADR group, ADR was administered 12 h after DOC injection; i n A DR&DOC g roup, bot h dr ugs w ere a dministered s imultaneously; i n control group, saline was administered at the same timing as ADR injection of other groups. Heart samples were isolated from all mice 1 week after the treatment.…

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