A third genotype of the human parvovirus PARV4 in sub-Saharan Africa

Simmonds, Peter; Douglas, Jill; Bestetti, Giovanna; Longhi, Erika; Antinori, Spinello; Parravicini, Carlo; Corbellino, Mario

doi:10.1099/vir.0.2008/001180-0

Cited by 64 publications

(80 citation statements)

References 14 publications

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“…38,[41][42][43][44]47 It has been found among infants in West Africa with no evidence of parenteral exposure. 35,36 Pediatric patients with HSCT J Rahiala et al…”

Section: Discussionmentioning

confidence: 99%

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Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Rahiala

Koskenvuo

Norja

et al. 2013

Bone Marrow Transplant

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Among the immunocompetent, infections with parvovirus B19 (B19V) and human bocavirus (HBoV) 1 range clinically from asymptomatic to severe, while following allogeneic hematopoietic SCT (HSCT) B19V can cause a persistent severe illness. The epidemiology and clinical impact of HBoV1 and the other emerging parvovirus 4 (PARV4) among immunocompromised patients have not been established. To determine the occurrence and clinical spectrum of B19V, PARV4 and HBoV1 infections, we performed a longitudinal molecular surveillance among 53 allogeneic HSCT recipients for pre-and post-HSCT DNAemias of these parvoviruses. Quantitative real-time PCR showed B19V DNA in sera of 16 (30%) patients, at mean levels of 4.6 Â 10 3 , 9.9 Â 10 7 , 1.1 Â 10 10 and 1.6 Â 10 2 B19V DNA copies/mL pre-HSCT (9/53), and at 1 (6/53), 2 (4/53) and 3 months (1/25) post HSCT, respectively. However, no clinical manifestation correlated with the presence of B19V viremia. All B19V sequences were of genotype 1. None of the sera investigated contained PARV4 or HBoV1 DNAs. Our data demonstrate B19V viremia to be frequent among pediatric allogeneic HSCT recipients, yet without apparent clinical correlates. PARV4 or HBoV1 viremias were not seen in these immunocompromised patients.

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“…38,[41][42][43][44]47 It has been found among infants in West Africa with no evidence of parenteral exposure. 35,36 Pediatric patients with HSCT J Rahiala et al…”

Section: Discussionmentioning

confidence: 99%

“…6 Three genotypes of PARV4 have been identified, two of them in Europe and one in Africa. 6,[34][35][36] The viral DNA has been shown to persist in lymphoid and some other tissues. [37][38][39][40][41] The virus is most frequently detected in persons with a history of i.v.…”

Section: Introductionmentioning

confidence: 99%

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Rahiala

Koskenvuo

Norja

et al. 2013

Bone Marrow Transplant

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“…Genotypes II and III were identified in 2006 and 2008, respectively (2,3). The nucleotide difference between genotypes I and II is about 8% in sequenced regions (3,4).…”

Section: Introductionmentioning

confidence: 99%

Frequency of human parvovirus 4 (PARV4) viremia among HBV-infected patients and healthy donors in Shiraz, Iran

et al. 2017

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Background/aim: PARV4, a small DNA virus belonging to the family Parvoviridae, was first isolated in an HBV injecting drug user. Several studies have investigated PARV4 co-infection with HBV and HCV and its effect on the progression of liver disease. The aim of this study was to determine the frequency of PARV4 among HBV-infected patients and healthy individuals. Materials and methods:A group of 90 HBV patients and a group of 90 healthy subjects were included in this study. Samples were selected after screening tests such as HBsAg ELISA, anti-HCV ELISA, and anti-HIV ELISA. Nested-PCRs were conducted to detect the PARV4 genome. Positive samples were then subjected to DNA sequencing.Results: PARV4 DNA was detected in 4.4% of HBV patients in comparison with 1.1% of healthy individuals (P-value: 0.36). DNA sequencing results revealed that PARV4 in all five positive samples was genotype I.Conclusions: Although this pilot study showed no significant difference between the frequency of PARV4 among HBV patients and healthy donors, further studies with a larger sample size are suggested to determine the association of PARV4 with HBV co-infection and the impact of this virus on the progression of liver disease in patients with hepatitis B.

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“…The three genotypes of PARV4 now identified (Simmonds et al, 2008) have not yet been related to any disease. However, 8 years elapsed between the discovery of B19 and its association with fifth disease (erythema infectiosum) (Anderson et al, 1983).…”

mentioning

confidence: 99%

“…It was identified by a random amplification of nucleic acids extracted from a patient with acute virus infection who was co-infected with hepatitis B virus (HBV) (Jones et al, 2005). Two further genotypes of PARV4 have now been described (Fryer et al, 2006;Simmonds et al, 2008). Very little is known about PARV4 and its biology.…”

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confidence: 99%

Parvovirus PARV4 visualization and detection

Tuke¹,

Parry²,

Appleton³

2009

Journal of General Virology

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The parvovirus PARV4 is the most recently described member of the family Parvoviridae that has a human host. To investigate the prevalence of PARV4 in blood, a quantitative TaqMan PCR was developed and plasma, sera or whole blood from a variety of population groups were examined. Eight samples were positive for PARV4, one at high copy number. The high-titre-positive plasma had an approximate viral load of 5¾10 8 genome equivalents ml "1. Two human sera, identified as PARV4 antibody-positive by indirect immunofluorescence, were used in immune electron microscopy to try to visualize native PARV4 within the high-titre human plasma. PARV4 particles were observed using one of these two sera. To our knowledge, this is the first time that native PARV4 has been visualized.

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A third genotype of the human parvovirus PARV4 in sub-Saharan Africa

Cited by 64 publications

References 14 publications

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Frequency of human parvovirus 4 (PARV4) viremia among HBV-infected patients and healthy donors in Shiraz, Iran

Parvovirus PARV4 visualization and detection

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