A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate

Wu, Jie; Su, Zhiguo; Ma, Guanghui

doi:10.1016/j.ijpharm.2006.01.045

Cited by 283 publications

(111 citation statements)

References 24 publications

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“…The initial burst release was relatively low: 12.26, 10.23, 5.98 and 4.24% of the drug was released within 8 h from samples CS-In1, 2, 3 and 4, respectively (Table 2 and Figure 3). A similar release profile was observed by other researchers (Wu et al, 2006(Wu et al, , 2007Kempe et al, 2008).…”

Section: In Vitro Insulin Releasesupporting

confidence: 90%

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In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

Tahrir¹,

Ganji²,

Mani

et al. 2014

Drug Delivery

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Injectable In situ gel-forming chitosan/b-glycerol phosphate (CS/b-Gp) solution can be introduced into the body in a minimally invasive manner prior to solidifying within the target tissue. This hydrogel is a good candidate for achieving a prolonged drug delivery system for insulin considering its high molecular weight. In addition to the physicochemical characterization of this hydrogel, in vitro and in vivo applications were studied as a sustained insulin delivery system. In the in vitro release studies, 19-63% of total insulin was released from the CS/b-Gp hydrogel within 150 h at different b-Gp and insulin concentrations. The best formulation was selected for in vivo experimentation to control the plasma glucose of diabetic mice models. The hypoglycemic effect of this formulation following subcutaneous injection in diabetic mice lasted 5 d, significantly longer than that of free insulin solution which lasted several hours.

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Section: In Vitro Insulin Releasesupporting

confidence: 90%

“…Wu et al (2006) showed the capacity of quaternized chitosan and poly(ethylene glycol) (PEG) with a small amount of a,b-Gp for insulin delivery. They showed that a HTCC-PEG-Gp formulation can be used as a nasal drug delivery system to improve the absorption of hydrophilic macromolecular drugs.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

Tahrir¹,

Ganji²,

Mani

et al. 2014

Drug Delivery

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“…The 1 H-NMR spectra of unmodified chitosan and HTCC are shown in Figure 1. A strong resonance at 3.2 ppm was observed in the HTCC spectrum, indicative of a trimethyl group of the quaternary ammonium side chain; however, this was not observed in the chitosan spectrum [10]. The resonances at around 4.8 ppm and 3.1 ppm were attributable to the H-1 and H-2 of glucosamine unit (GlcN), respectively, in both chitosan and HTCC spectra [11].…”

Section: Synthesis and Characterization Of Htccmentioning

confidence: 98%

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

et al. 2016

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Abstract:The objective of this study is to develop suitable formulations to improve the dissolution rate of poorly water soluble drugs. We selected lipid-based formulation as a drug carrier and modified the surface using positively charged chitosan derivative (HTCC) to increase its water solubility and bioavailability. Chitosan and HTCC-coated lipid particles had higher zeta-potential values than uncoated one over the whole pH ranges and improved encapsulation efficiency. In vitro drug release showed that all NLC formulations showed higher in vitro release efficiency than drug particle at pH 7.4. Furthermore, NLC formulation prepared with chitosan or HTCC represented good sustained release property. The results indicate that chitosan and HTCC can be excellent formulating excipients of lipid-based delivery carrier for improving poorly water soluble drug delivery.

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“…Cs-GP system has a great potential as scaffold material in tissue engineering and regenerative medicine due to its good biocompatibility, minimal immune reaction, high antibacterial nature, good adhesion to cells and the possibility to be moulded in various geometries [18][19][20][21][22][23][24][25][26]. For similar reasons, the other key pharmaceutical application of this material is a smart-controlled release system [4,18,20,[27][28][29][30][31][32][33][34][35][36][37][38], because the hydrogel is able to keep the drug level within the therapeutic window during extended periods of time, thus avoiding frequent low doses and undesirable secondary effects in patients. Important and interesting patents of biomedical applications of this system have been revised recently [39].…”

Section: Applicationsmentioning

confidence: 99%

Chitosan-Based Thermosensitive Materials

Argüelles‐Monal¹,

Recillas-Mota²,

Fernández‐Quiroz³

2017

Biological Activities and Application of Marine Polysaccharides

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Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.

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A thermo- and pH-sensitive hydrogel composed of quaternized chitosan/glycerophosphate

Cited by 283 publications

References 24 publications

In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

In vitro and in vivo evaluation of thermosensitive chitosan hydrogel for sustained release of insulin

Positively Charged Nanostructured Lipid Carriers and Their Effect on the Dissolution of Poorly Soluble Drugs

Chitosan-Based Thermosensitive Materials

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