2008
DOI: 10.1016/j.stem.2007.10.006
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The temporal switch from progenitor cell proliferation to differentiation is essential for effective adult tissue repair. We previously reported the critical role of Notch signaling in the proliferative expansion of myogenic progenitors in mammalian postnatal myogenesis. We now show that the onset of differentiation is due to a transition from Notch signaling to Wnt signaling in myogenic progenitors and is associated with an increased expression of Wnt in the tissue and an increased responsiveness of progenito… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

35
549
3
10

Year Published

2010
2010
2016
2016

Publication Types

Select...
4
4

Relationship

0
8

Authors

Journals

citations
Cited by 538 publications
(597 citation statements)
references
References 36 publications
35
549
3
10
Order By: Relevance
“…For example, activation of the noncanonical WNT/ planar cell polarity pathway promotes the expansion of satellite cells by stimulating symmetric cell divisions to produce two daughter satellite cells during the self-renewal process (36). By contrast, injury-induced muscle regeneration results in canonical WNT/β-catenin pathway activation and myogenic differentiation of satellite cells (18). These studies suggest that canonical and noncanonical pathways play antagonistic roles in regulating satellite cell function.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…For example, activation of the noncanonical WNT/ planar cell polarity pathway promotes the expansion of satellite cells by stimulating symmetric cell divisions to produce two daughter satellite cells during the self-renewal process (36). By contrast, injury-induced muscle regeneration results in canonical WNT/β-catenin pathway activation and myogenic differentiation of satellite cells (18). These studies suggest that canonical and noncanonical pathways play antagonistic roles in regulating satellite cell function.…”
Section: Discussionmentioning
confidence: 99%
“…Additional molecular pathways that regulate satellite cell self-renewal also have important roles in ERMS. For example, the Notch pathway promotes activation and proliferation of satellite cells during regeneration (18). In human ERMS cells, knockdown of the Notch1-Hey1 axis or Notch3 resulted in reduced tumor cell growth and enhanced myogenic differentiation (37,38), suggesting that the Notch pathway may regulate self-renewal and differentiation of human ERMS.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In some normal adult tissues, Wnt / β -catenin signalling activity has been shown to mainly reside in stem or progenitor cells and to increase upon injury 17,18,49 . Interestingly, stem or progenitor cells are suggested to be fusion partners of transplanted bone marrowderived cells in tissue regeneration, at least in the intestine 3 .…”
Section: Discussionmentioning
confidence: 99%
“…They are known to function at distinct phases of regeneration: with Notch functioning at the early phase to promote satellite cell activation and proliferation and Wnt at the later phase to promote myoblast differentiation [24][25][26]. In addition to Notch and Wnt, members of the interleukin-6 (IL-6) family of cytokines are also implicated in muscle differentiation and regeneration.…”
Section: Introductionmentioning
confidence: 99%