A targeted agent with intercalation structure for cancer near-infrared imaging and photothermal therapy

Li, Chunyang; Liang, Ruizheng; Tian, Rui; Guan, Shanyue; Yan, Dongpeng; Luo, Jiaoyang; Wei, Min; Evans, David G.; Duan, Xue

doi:10.1039/c5ra23686j

Cited by 22 publications

(13 citation statements)

References 53 publications

(54 reference statements)

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“…According to the previous reports, ,,− the formation of J-aggregates of ICG molecules in LDH-based or Ag-based nanohybrids usually caused a relatively small redshift of ICG characteristic peak at about 20 to 50 nm. However, it was well known that modifying the electronic structure of π-conjugated organic compounds ( e.g.…”

Section: Results and Discussionmentioning

confidence: 82%

Electron Donor–Acceptor Effect-Induced Organic/Inorganic Nanohybrids with Low Energy Gap for Highly Efficient Photothermal Therapy

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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For the design and optimization of near-infrared photothermal nanohybrids, tailoring the energy gap of nanohybrids plays a crucial role in attaining a satisfactory photothermal therapeutic efficacy for cancer and remains a challenge. Herein, we report an electron donor−acceptor effect-induced organic/ inorganic nanohybrid with a low energy gap (denoted as ICG/Ag/ LDH) by the in situ deposition of Ag nanoparticles onto the CoAl−LDH surface, followed by the coupling of ICG. A combination study verifies that the supported Ag nanoparticles as the electron donor (D) push electrons into the conjugated system of ICG by the electronic interaction between ICG and Ag, while OH groups of LDHs as the electron acceptor (A) pull electrons from the conjugated system of ICG by hydrogen bonding (N•••H−O). This induces the formation of the D−A conjugated π-system and has a strong influence on the π-conjugated system of ICG, thus leading to a prominent decrease toward the energy gap and correspondingly an ultra-long redshift (∼115 nm). The resulting ICG/Ag/LDHs show an enhanced photothermal conversion efficiency (∼45.5%) at 808 nm laser exposure, which is ∼1.6 times larger than that of ICG (∼28.4%). Such a high photothermal performance is attributed to the fact that ICG/Ag/LDHs possess a D−π−A hybrid structure and a resulting lower energy gap, thus effectively promoting nonradiative transitions and leading to enhancement of the photothermal effect. Both in vitro and in vivo results confirm the good biocompatible properties and capability of the ICG/Ag/LDHs for NIR-triggered cancer treatment. This research demonstrates a successful paradigm for the rational design and preparation of new nanohybrids through the modulation of electron donor−acceptor effect, which offers a new avenue to achieve efficient phototherapeutic agent for improving the cancer therapeutic outcomes.

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Section: Results and Discussionmentioning

confidence: 82%

Electron Donor–Acceptor Effect-Induced Organic/Inorganic Nanohybrids with Low Energy Gap for Highly Efficient Photothermal Therapy

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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“…Finally, FA molecules were conjugated onto MT@L-PTX, and the final nanosystem MT@L-PTX@FA was obtained (Figure S8 revealed that the hydrodynamic size of MT@L-PTX@FA obtained from DLS was about 250 nm). As shown in Figure S9, the FT-IR spectra of MT@L-PTX@FA exhibited additional absorption bands at 1639 and 1401 cm –1 in comparison with that of MT@L-PTX, which were assigned to the symmetrical ν s (CO) and asymmetric ν as (CO) vibrations of FA, respectively, indicating the successful conjugation of FA.…”

Section: Resultsmentioning

confidence: 98%

In Situ Formation of Homogeneous Tellurium Nanodots in Paclitaxel-Loaded MgAl Layered Double Hydroxide Gated Mesoporous Silica Nanoparticles for Synergistic Chemo/PDT/PTT Trimode Combinatorial Therapy

et al. 2019

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A folic acid (FA) functional drug delivery system (MT@L-PTX@FA) based on in situ formation of tellurium nanodots (Te NDs) in paclitaxel (PTX)-loaded MgAl layered double hydroxide (LDHs) gated mesoporous silica nanoparticles (MSNs) has been designed and fabricated for targeted chemo/PDT/PTT trimode combinatorial therapy. X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), N2 adsorption–desorption, Fourier transform infrared (FT-IR) spectra, and UV–vis spectra were used to demonstrate the successful fabrication of MT@L-PTX@FA. In particular, the in situ generated Te NDs showed a homogeneous ultrasmall size. Reactive oxygen species (ROS) generation, photothermal effects, and photostability evaluations indicated that the in situ generated homogeneous Te NDs could serve as the phototherapeutic agent, converting the photon energy to ROS and heat under near-infrared (NIR) irradiation efficiently. The drug-release test revealed that MT@L-PTX@FA showed an apparent sustained release character in a pH-sensitive manner. In addition, cell imaging experiments demonstrated that MT@L-PTX@FA could selectively enter into cancer cells owing to the function of FA and release of PTX efficiently for chemotherapy for the reason that the low intracellular pH would dissolve MgAl LDHs to Mg2+ and Al3+. Cytotoxicity tests also indicated that MT@L-PTX@FA exhibited enhanced therapeutic effect in cancer cells under NIR irradiation, benefiting from the synergy based on targeted chemo/PDT/PTT trimode combinatorial therapy. The preliminary results reported here will shed new light on the future design and applications of nanosystems for synergistic combinatorial therapy.

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“…Materials based on LDHs can be used as efficient HER and OER electrocatalysts due to their special layered structure, tunable band gaps, scale-up facility, great photocatalytic ability, and inexpensiveness. What is more, LDH microcrystals can be employed as monolayer nanosheets in fabricating electrocatalysts [30,31]. LDHs are made up of transition metal cations, especially Ti, Co, Fe, Ni, Mg, and Zn and are extensively employed in electrocatalytic reactions, particularly for HER and OER [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Enhancing water splitting via weakening H2 and O2 adsorption on NiCo-LDH@CdS due to interstitial nitrogen doping: A close look at the mechanism of electron transfer

Pirkarami

Rasouli

Ghasemi

2021

Journal of Energy Chemistry

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A targeted agent with intercalation structure for cancer near-infrared imaging and photothermal therapy

Abstract: A new targeted photothermal agent is synthesized by co-intercalation of indocyanine green (ICG) and folic acid (FA) into the layered double hydroxide (LDH), which can be potentially used in cancer NIR imaging and photothermal therapy (PTT) field.

Cited by 22 publications

References 53 publications

Electron Donor–Acceptor Effect-Induced Organic/Inorganic Nanohybrids with Low Energy Gap for Highly Efficient Photothermal Therapy

Electron Donor–Acceptor Effect-Induced Organic/Inorganic Nanohybrids with Low Energy Gap for Highly Efficient Photothermal Therapy

In Situ Formation of Homogeneous Tellurium Nanodots in Paclitaxel-Loaded MgAl Layered Double Hydroxide Gated Mesoporous Silica Nanoparticles for Synergistic Chemo/PDT/PTT Trimode Combinatorial Therapy

Enhancing water splitting via weakening H2 and O2 adsorption on NiCo-LDH@CdS due to interstitial nitrogen doping: A close look at the mechanism of electron transfer

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