A tale of two countries: comparing disability weights for gambling problems in New Zealand and Australia

Rawat, Vijay; Browne, Matthew; Bellringer, Maria; Greer, Nancy; Kolandai-Matchett, Komathi; Langham, Erika; Hanley, Christine; Preez, Katie Palmer du; Abbott, Max

doi:10.1007/s11136-018-1882-8

Cited by 25 publications

(19 citation statements)

References 26 publications

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“…Harmful gambling can be challenging to define, both conceptually and empirically (for a more in-depth discussion see Browne, Greer, Rawat, & Rockloff, 2017;Delfabbro & King, 2019;Rawat, Browne, Bellringer et al, 2018). A broad definition of harmful gambling advanced for the Framework is:…”

Section: About the Frameworkmentioning

confidence: 99%

The Conceptual Framework of Harmful Gambling: A revised framework for understanding gambling harm

Hilbrecht

Baxter

Abbott

et al. 2020

Journal of Behavioral Addictions

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Background and aims The Conceptual Framework of Harmful Gambling moves beyond a symptoms-based view of harm and addresses a broad set of factors related to the risks and effects of gambling harmfully at the individual, family, and community levels. Coauthored by international research experts and informed by multiple stakeholders, Gambling Research Exchange (GREO) facilitated the framework development in 2013 and retains responsibility for regular updates and mobilization. This review article presents information about the revised version of the Conceptual Framework of Harmful Gambling completed in late 2018. Methods We describe eight interrelated factors depicted in the framework that represent major themes in gambling ranging from the specific (gambling environment, exposure, gambling types, and treatment resources) to the general (cultural, social, psychological, and biological influences). After outlining the framework development and collaborative process, we highlight new topics for the recent update that reflect changes in the gambling landscape and prominent discourses in the scientific community. Some of these topics include social and economic impacts of gambling, and a new model of understanding gambling related harm. Discussion and conclusions We address the relevance of the CFHG to the gambling and behavioral addictions research community. Harm-based frameworks have been undertaken in other areas of addiction that can both inform and be informed by a model dedicated to harmful gambling. Further, the framework brings a multi-disciplinary perspective to bear on antecedents and factors that co-occur with harmful gambling.

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Section: About the Frameworkmentioning

confidence: 99%

The Conceptual Framework of Harmful Gambling: A revised framework for understanding gambling harm

Hilbrecht

Baxter

Abbott

et al. 2020

Journal of Behavioral Addictions

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“…Strikingly, long-term studies on the nephrotoxic action of drugs administered during active nephrogenesis are mostly lacking. Still, several acute toxic and teratogenic effects on human kidney development have been described, amongst others, for angiotensin-converting enzyme (ACE) inhibitors ( Mastrobattista, 1997 ), angiotensin type 1 (AT1) receptor antagonists ( Hinsberger et al, 2001 ; Boubred et al, 2006 ; Payen et al, 2006 ) and non-steroidal anti-inflammatory drugs (NSAID) ( Boubred et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

“…Despite being a member of the teleost family, there are high similarities at the developmental and cell- and organ-specific level between zebrafish and humans ( Hinsberger et al, 2001 ). The pronephros of the zebrafish larva consists of two nephrons with a fused glomerulus ventrally to the dorsal aorta.…”

Section: Introductionmentioning

confidence: 99%

In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs

Westhoff

Steenbergen

Thomas

et al. 2020

Front. Cell Dev. Biol.

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Despite widespread drug exposure, for example during gestation or in prematurely born children, organ-specific developmental toxicity of most drugs is poorly understood. Developmental and functional abnormalities are a major cause of kidney diseases during childhood; however, the potential causal relationship to exposure with nephrotoxic drugs during nephrogenesis is widely unknown. To identify developmental nephrotoxic drugs in a large scale, we established and performed an automated high-content screen to score for phenotypic renal alterations in the Tg(wt1b:EGFP) zebrafish line. During early nephrogenesis, embryos were exposed to a compound library of approved drugs. After treatment, embryos were aligned within microtiter plates using 3Dprinted orientation tools enabling the robust acquisition of consistent dorsal views of pronephric kidneys by automated microscopy. To qualitatively and quantitatively score and visualize phenotypes, we developed software tools for the semi-automated analysis, processing and visualization of this large image-based dataset. Using this scoring scheme, we were able to categorize compounds based on their potential developmental nephrotoxic effects. About 10% of tested drugs induced pronephric phenotypes including glomerular and tubular malformations, or overall changes in kidney morphology. Major chemical compound groups identified to cause glomerular and tubular alterations included dihydropyridine derivatives, HMG CoA reductase inhibitors, fibrates, imidazole, benzimidazole and triazole derivatives, corticosteroids, glucocorticoids, acetic acid derivatives and propionic acid derivatives. In conclusion, the presented study demonstrates the large-scale screening of kidney-specific toxicity of approved drugs in a live vertebrate embryo. The associated technology and tool-sets can be easily adapted for other organ systems providing a unique platform for in vivo large-scale assessment of organ-specific developmental toxicity or other biomedical applications. Ultimately, the presented data and associated visualization and browsing tools provide a resource for potentially nephrotoxic drugs and for further investigations.

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“…The first observation that cancer cells from the primary tumor are “primed” to colonize a specific tissue comes from the “seed and soil” theory of Stephen Paget declared in 1889 ( Paget, 1889 ). In his theory, Paget compared cancer cells leaving the primary tumor to seeds that germinate only when sowed in a suitable soil (target organ/tissue).…”

Section: Introductionmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.

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A tale of two countries: comparing disability weights for gambling problems in New Zealand and Australia

Cited by 25 publications

References 26 publications

The Conceptual Framework of Harmful Gambling: A revised framework for understanding gambling harm

The Conceptual Framework of Harmful Gambling: A revised framework for understanding gambling harm

In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

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