2009
DOI: 10.1016/j.devcel.2009.10.011
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Abstract: SUMMARY We created a whole-mount in situ hybridization (WISH) database, termed EMBRYS, containing expression data of 1520 transcription factors and cofactors expressed in E9.5, E10.5, and E11.5 mouse embryos—a highly dynamic stage of skeletal myogenesis. This approach implicated 43 genes in regulation of embryonic myogenesis, including a transcriptional repressor, the zinc-finger protein RP58 (also known as Zfp238). Knockout and knockdown approaches confirmed an essential role for RP58 in skeletal myogenesis. … Show more

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Cited by 134 publications
(148 citation statements)
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“…MAZ (mycassociated zinc-finger protein) has been shown to regulate musclespecific gene expression. 30 RP58 has an essential role in skeletal myogenesis, 31 and BLIMP1 is involved in myocyte differentiation. 32 CIZ is implicated in regulation of bone mass biology.…”
Section: Discussionmentioning
confidence: 99%
“…MAZ (mycassociated zinc-finger protein) has been shown to regulate musclespecific gene expression. 30 RP58 has an essential role in skeletal myogenesis, 31 and BLIMP1 is involved in myocyte differentiation. 32 CIZ is implicated in regulation of bone mass biology.…”
Section: Discussionmentioning
confidence: 99%
“…Initial characterization of mouse Mkx revealed a dynamic transcription pattern restricted to progenitors of tendon, skeletal muscle, and cartilage, as well as the sex chords of the male gonad and the ureteric bud tip of the metanephrogenic kidney (19,25,26). We previously identified Mkx as a transcription factor expressed in developing tendons by constructing a wholemount in situ hybridization database, termed "EMBRYS" (http:// embrys.jp/embrys/html/MainMenu.html), which contains expression data of 1,520 transcription factors and cofactors expressed in E9.5, E10.5, and E11.5 mouse embryos (27).To investigate the in vivo functions of Mkx, we generated Mkx knockout mice. Here, we show that Mkx null mice have hypoplastic tendons throughout their body.…”
mentioning
confidence: 99%
“…However, in mice, the absence of p73 does not affect limb development (Yang et al, 2000). This may be because levels of p73 transcripts are very low in mouse limb buds (EMBRYS; http://embrys.jp/embrys/html/MainMenu.html; Yokoyama et al, 2009) when compared with those in chick limb buds (Fig. 4H,I).…”
Section: Discussionmentioning
confidence: 88%
“…Notably, however, the expression of many AP-1 family members, including MafB and cFos, differs between the limb buds of chick and mouse embryos (supplementary material Fig. S1; EMBRYS; Yokoyama et al, 2009). In mice, MafB is not expressed in the apical ridge and cFos transcripts are not detectable in limb buds (EMBRYS; Yokoyama et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
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