“…This is particularly relevant in preclinical species that are commonly used in academic research and for the evaluation of drug candidates by the pharmaceutical industry. Recently [63], rats were shown to exhibit a higher hepatic basal NRF2 activity compared with mice, along with a stronger activation of the pathway when the two species were challenged with pharmacokinetically equivalent doses of the hepatotoxin acetaminophen. By extending the analysis of the basal activity of NRF2 to normal liver samples from patients, it was found that mice better reflect the typical NRF2 activity of humans.…”