A Systematized Review of Atypical Antipsychotics in Pregnant Women

Abstract

After taking into account the parents' will and after they provide informed consent, the most reasonable and less harmful choice for treating future mothers with bipolar disorder or schizophrenia appears to be maintaining them at the safest minimum dosage.

Long-acting antipsychotic treatments: focus on women with schizophrenia

“…Regarding LAP-APs formulations, special caution should be taken in cases of women at risk for preterm delivery. Having SZ and the exposure to SGAs itself may be related to a slight increase in the risk of preterm birth and low birth weight 87 ; in these cases, the clinician may consider avoiding administering an LAI to women who strictly plan to breastfeed as preterm infants are at risk for elevated plasma medication concentrations due to immature hepatic and renal systems. 88 Impact on prolactin, a key hormone in the lactation process, should also be considered; aripiprazole a partial agonist of the dopamine receptor often reduces prolactin levels, 89 and may negatively affect lactation.…”

Long-acting antipsychotic treatments: focus on women with schizophrenia

“…Regarding LAP-APs formulations, special caution should be taken in cases of women at risk for preterm delivery. Having SZ and the exposure to SGAs itself may be related to a slight increase in the risk of preterm birth and low birth weight 87 ; in these cases, the clinician may consider avoiding administering an LAI to women who strictly plan to breastfeed as preterm infants are at risk for elevated plasma medication concentrations due to immature hepatic and renal systems. 88 Impact on prolactin, a key hormone in the lactation process, should also be considered; aripiprazole a partial agonist of the dopamine receptor often reduces prolactin levels, 89 and may negatively affect lactation.…”

Treatment With Long-Acting Injectable Aripiprazole During Pregnancy in Bipolar Disorder: A Scoping Review

“…Prioritizing the prescription of LAIs to pregnant individuals when the significant risks of psychiatric decompensation outweigh the absence of data can be life changing to the patient and the future baby. 5…”

Descriptive Characteristics of Psychiatric Medication Discontinuation Among Perinatal Women With Depressive Symptoms

“…Discontinuation of antidepressants during pregnancy has been linked to higher risks of relapse, psychiatric emergencies, depression-related hospitalizations, and self-harm, particularly for those with severe or recurrent depression ( Cohen et al, 2006 ; Swanson et al, 2015 ; Tosato et al, 2017 ; Bayrampour et al, 2020 ; Liu et al, 2022 ). These adverse effects may be mitigated when discontinuation occurs prior to pregnancy rather than abruptly during gestation ( Liu et al, 2022 ).…”

Long-acting antipsychotic treatments: focus on women with schizophrenia

“…Regarding LAP-APs formulations, special caution should be taken in cases of women at risk for preterm delivery. Having SZ and the exposure to SGAs itself may be related to a slight increase in the risk of preterm birth and low birth weight 87 ; in these cases, the clinician may consider avoiding administering an LAI to women who strictly plan to breastfeed as preterm infants are at risk for elevated plasma medication concentrations due to immature hepatic and renal systems. 88 Impact on prolactin, a key hormone in the lactation process, should also be considered; aripiprazole a partial agonist of the dopamine receptor often reduces prolactin levels, 89 and may negatively affect lactation.…”

Treatment With Long-Acting Injectable Aripiprazole During Pregnancy in Bipolar Disorder: A Scoping Review

“…Prioritizing the prescription of LAIs to pregnant individuals when the significant risks of psychiatric decompensation outweigh the absence of data can be life changing to the patient and the future baby. 5…”

Descriptive Characteristics of Psychiatric Medication Discontinuation Among Perinatal Women With Depressive Symptoms

“…Discontinuation of antidepressants during pregnancy has been linked to higher risks of relapse, psychiatric emergencies, depression-related hospitalizations, and self-harm, particularly for those with severe or recurrent depression ( Cohen et al, 2006 ; Swanson et al, 2015 ; Tosato et al, 2017 ; Bayrampour et al, 2020 ; Liu et al, 2022 ). These adverse effects may be mitigated when discontinuation occurs prior to pregnancy rather than abruptly during gestation ( Liu et al, 2022 ).…”

Long-acting antipsychotic treatments: focus on women with schizophrenia

“…Regarding LAP-APs formulations, special caution should be taken in cases of women at risk for preterm delivery. Having SZ and the exposure to SGAs itself may be related to a slight increase in the risk of preterm birth and low birth weight 87 ; in these cases, the clinician may consider avoiding administering an LAI to women who strictly plan to breastfeed as preterm infants are at risk for elevated plasma medication concentrations due to immature hepatic and renal systems. 88 Impact on prolactin, a key hormone in the lactation process, should also be considered; aripiprazole a partial agonist of the dopamine receptor often reduces prolactin levels, 89 and may negatively affect lactation.…”

Treatment With Long-Acting Injectable Aripiprazole During Pregnancy in Bipolar Disorder: A Scoping Review

“…Prioritizing the prescription of LAIs to pregnant individuals when the significant risks of psychiatric decompensation outweigh the absence of data can be life changing to the patient and the future baby. 5…”

Descriptive Characteristics of Psychiatric Medication Discontinuation Among Perinatal Women With Depressive Symptoms

“…Discontinuation of antidepressants during pregnancy has been linked to higher risks of relapse, psychiatric emergencies, depression-related hospitalizations, and self-harm, particularly for those with severe or recurrent depression ( Cohen et al, 2006 ; Swanson et al, 2015 ; Tosato et al, 2017 ; Bayrampour et al, 2020 ; Liu et al, 2022 ). These adverse effects may be mitigated when discontinuation occurs prior to pregnancy rather than abruptly during gestation ( Liu et al, 2022 ).…”