A systematic surface studies on the glycolipids to understand the surface adsorption behavior

Sekhar, Kanaparedu P. C.; Bangal, Prakriti Ranjan; Nayak, Rati Ranjan

doi:10.1016/j.colsurfa.2018.12.007

Cited by 12 publications

(10 citation statements)

References 55 publications

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“…The droplets were put in the presence of increasing concentrations of mannolipid from 20 to 400 μM in the buffer. Because molar concentrations are a poor description for surface functionalization, we converted the concentrations into surface equivalents assuming a surface excess of 50 Å 2 for the mannolipid, as was previously reported for linear glycolipid with a single sugar unit and comparable chain lengths . We worked with 2.3 × 10 7 droplets of 10 μm diameter, which corresponds to 7.2 × 10 9 μm 2 of total droplets surface.…”

Section: Results and Discussionmentioning

confidence: 99%

“…Because molar concentrations are a poor description for surface functionalization, we converted the concentrations into surface equivalents assuming a surface excess of 50 Å 2 for the mannolipid, as was previously reported for linear glycolipid with a single sugar unit and comparable chain lengths. 44 We worked with 2.3 × 10 7 droplets of 10 μm diameter, which corresponds to 7.2 × 10 9 μm 2 of total droplets surface. In these conditions, 1 surface equivalent corresponds to 100 μM of mannolipid in a 250 μL working volume.…”

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

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Mannose-Coated Fluorescent Lipid Microparticles for Specific Cellular Targeting and Internalization via Glycoreceptor-Induced Phagocytosis

Dumat

Montel

Pinon

et al. 2019

ACS Appl. Bio Mater.

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In this work we report on the development of mannose-coated fluorescent lipid microparticles to study the role of C-type lectin membrane receptor in phagocytosis. The micrometric droplets of soybean oil in water emulsion were functionalized with a tailor-made fluorescent mannolipid. The amphiphilic ligand was built from a mannose unit, a lipid C11 spacer and a naphthalimide fluorophore. The droplets functionalization was monitored by fluorescence microscopy as well as the interaction with concanavalin A which was used as a model lectin in vitro. The use of a monovalent ligand on the surface of emulsion droplets yielded particles with an affinity approximately 40 times higher than that of free mannose. In cellulo, the coated droplets were shown to be specifically internalized by macrophages in a receptor-dependent phagocytic pathway. The naked droplets on the other hand display very little internalization due to their low immunogenicity. This work thus brings evidence that C-type lectin membrane receptors may act as phagocytic receptors. The droplets functionalization with the tailored amphiphilic fluorescent ligand and the droplets functionalization also provides insights into the development of organic fluorescent particles that may prove useful for developing targeted imaging and delivery tools.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Acs Applied Bio Materialsmentioning

confidence: 99%

Mannose-Coated Fluorescent Lipid Microparticles for Specific Cellular Targeting and Internalization via Glycoreceptor-Induced Phagocytosis

Dumat

Montel

Pinon

et al. 2019

ACS Appl. Bio Mater.

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“…A is the minimum area occupied by each surfactant molecule. Further, the surface tension reduction (𝜋 𝐶𝑀𝐶 ), represents the lowering of the solvent surface tension at CMC and be calculated by using the following equation [42]:…”

Section: A Values the Increase In Minmentioning

confidence: 99%

Thermodynamics and Micellar Behavior of Surface-Active Drugs in Aqueous Solution of Electrolytes: Surface Tension Study

Sharma¹,

Singh²,

Sharma³

et al. 2022

SSRN Journal

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“…In the context of our previous work, we were interested in scrutinizing the self-assembled gelation behavior of glycolipids with an increase in chain length and headgroup size. Synthesis, surface, self-assembly properties, and applications of glycolipid amphiphiles employed in this work have been reported earlier. − In this work, formulation of multifunctional hydro-/organogels with biomedical applications from biobased LMWG glycolipids was targeted. This simple method of varying the chain length and headgroup size helped us study their effect over the gelation phenomenon.…”

Section: Introductionmentioning

confidence: 97%

Supramolecular Glycolipid-Based Hydro-/Organogels with Enzymatic Bioactive Release Ability by Tuning the Chain Length and Headgroup Size

Holey

Sekhar

Swain

et al. 2022

ACS Biomater. Sci. Eng.

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Designing of supramolecular hydro-/organogels having desired properties, biocompatibility, and stimuli responsiveness is a challenging task. Herein, the gelation ability of amphiphilic glycolipid-based gelators in a wide range of solvents is explored. The structure–function relationship was established by varying the chain length and polar headgroup size of amphiphilic gelators. The prepared hydro-/organogels were characterized by employing several techniques such as differential scanning calorimetry (DSC), rheology, field emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), etc. The thermal stability of hydro-/organogels increased with an increase in chain length. Rheological analysis depicted that variation in chain length and headgroup size of amphiphilic gelators significantly affected the gel strength and stability. The self-assembled morphology of hydro-/organogel samples revealed the compact entangled fibrillar network structures. After comparing the energy-minimized molecular length with the d-spacing value obtained by XRD, interdigitated bilayer packing in the gel network was established. The bioactive encapsulation and enzymatic release study of hydro-/organogels portrayed their potential application in the biomedical field. To our delight, glycolipid 16M (C16 chain length) formed a molecular hydrogel with injectable and thixotropic behaviors. High critical strain value, thixotropy, injectability, thermoreversibility, and faster bioactive release for the 16M-W hydrogel proved crucial to predict its future applications. Overall, glycolipid amphiphiles designed by upholding proper hydrophilic–lipophilic balance can form multifunctional supramolecular hydrogels with excellent implementation in the drug delivery system.

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A systematic surface studies on the glycolipids to understand the surface adsorption behavior

Cited by 12 publications

References 55 publications

Mannose-Coated Fluorescent Lipid Microparticles for Specific Cellular Targeting and Internalization via Glycoreceptor-Induced Phagocytosis

Mannose-Coated Fluorescent Lipid Microparticles for Specific Cellular Targeting and Internalization via Glycoreceptor-Induced Phagocytosis

Thermodynamics and Micellar Behavior of Surface-Active Drugs in Aqueous Solution of Electrolytes: Surface Tension Study

Supramolecular Glycolipid-Based Hydro-/Organogels with Enzymatic Bioactive Release Ability by Tuning the Chain Length and Headgroup Size

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