A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis

Abstract

There is consistent evidence from small high-quality studies that red and infrared LLLT can partly prevent development of cancer therapy-induced OM. LLLT also significantly reduced pain, severity and duration of symptoms in patients with cancer therapy-induced OM.

Evaluating high power laser therapy (HPLT) as treatment for chemotherapy‐induced oral mucositis in paediatric patients with oncohematological diseases

“…In a retrospective study, Zecha et al 17 concluded that it seems unlikely that PBM has carcinogenic effects on normal cells as the nonionizing wavelengths of the red and NIR spectrum used in PBM are far longer than the safety limit of 320 nm for DNA damage. Moreover, in our study, no short‐term side effect was observed, and this is in accordance with many studies in the literature 18,19 …”

Evaluating high power laser therapy (HPLT) as treatment for chemotherapy‐induced oral mucositis in paediatric patients with oncohematological diseases

“…In a retrospective study, Zecha et al 17 concluded that it seems unlikely that PBM has carcinogenic effects on normal cells as the nonionizing wavelengths of the red and NIR spectrum used in PBM are far longer than the safety limit of 320 nm for DNA damage. Moreover, in our study, no short‐term side effect was observed, and this is in accordance with many studies in the literature 18,19 …”

Oral mucositis in paediatric cancer patients undergoing allogeneic hematopoietic stem cell transplantation preventively treated with professional dental care and photobiomodulation: Incidence and risk factors

“…The incidence rate of OM in pediatric patients in our study was 73.5% for all grades and 23.5% for severe OM, which is in line with the results found in studies with the same population 2‐5 . The therapeutic approaches to avoid OM development are not available, but the prophylactic use of PDC 25‐27 and PBM 1,15,28‐31 has been reported to reduce the incidence and severity of this toxicity in cancer patients. Both incidence and severity of OM were shown to decrease after the application of PBM and PDC, 1 which was also confirmed in this study.…”

Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy

“…In our study, all patients in both the laser and control groups showed some grade of mucositis, but laser group had the harmful effects of cancer treatment to the oral mucosa minimized. Similar results have been reported previously . A systematic review and meta‐analysis of randomized placebo‐controlled trials of low‐level laser therapy for patients submitted to cancer chemotherapy or radiation therapy in the head and neck found 11 studies with acceptable methodological .…”

Evaluating high power laser therapy (HPLT) as treatment for chemotherapy‐induced oral mucositis in paediatric patients with oncohematological diseases

“…In a retrospective study, Zecha et al 17 concluded that it seems unlikely that PBM has carcinogenic effects on normal cells as the nonionizing wavelengths of the red and NIR spectrum used in PBM are far longer than the safety limit of 320 nm for DNA damage. Moreover, in our study, no short‐term side effect was observed, and this is in accordance with many studies in the literature 18,19 …”

Oral mucositis in paediatric cancer patients undergoing allogeneic hematopoietic stem cell transplantation preventively treated with professional dental care and photobiomodulation: Incidence and risk factors

“…The incidence rate of OM in pediatric patients in our study was 73.5% for all grades and 23.5% for severe OM, which is in line with the results found in studies with the same population 2‐5 . The therapeutic approaches to avoid OM development are not available, but the prophylactic use of PDC 25‐27 and PBM 1,15,28‐31 has been reported to reduce the incidence and severity of this toxicity in cancer patients. Both incidence and severity of OM were shown to decrease after the application of PBM and PDC, 1 which was also confirmed in this study.…”

Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy

“…In our study, all patients in both the laser and control groups showed some grade of mucositis, but laser group had the harmful effects of cancer treatment to the oral mucosa minimized. Similar results have been reported previously . A systematic review and meta‐analysis of randomized placebo‐controlled trials of low‐level laser therapy for patients submitted to cancer chemotherapy or radiation therapy in the head and neck found 11 studies with acceptable methodological .…”

Evaluating high power laser therapy (HPLT) as treatment for chemotherapy‐induced oral mucositis in paediatric patients with oncohematological diseases

“…In a retrospective study, Zecha et al 17 concluded that it seems unlikely that PBM has carcinogenic effects on normal cells as the nonionizing wavelengths of the red and NIR spectrum used in PBM are far longer than the safety limit of 320 nm for DNA damage. Moreover, in our study, no short‐term side effect was observed, and this is in accordance with many studies in the literature 18,19 …”

Oral mucositis in paediatric cancer patients undergoing allogeneic hematopoietic stem cell transplantation preventively treated with professional dental care and photobiomodulation: Incidence and risk factors

“…The incidence rate of OM in pediatric patients in our study was 73.5% for all grades and 23.5% for severe OM, which is in line with the results found in studies with the same population 2‐5 . The therapeutic approaches to avoid OM development are not available, but the prophylactic use of PDC 25‐27 and PBM 1,15,28‐31 has been reported to reduce the incidence and severity of this toxicity in cancer patients. Both incidence and severity of OM were shown to decrease after the application of PBM and PDC, 1 which was also confirmed in this study.…”

Effect of low level laser therapy in the reduction of oral complications in patients with cancer of the head and neck submitted to radiotherapy

“…In our study, all patients in both the laser and control groups showed some grade of mucositis, but laser group had the harmful effects of cancer treatment to the oral mucosa minimized. Similar results have been reported previously . A systematic review and meta‐analysis of randomized placebo‐controlled trials of low‐level laser therapy for patients submitted to cancer chemotherapy or radiation therapy in the head and neck found 11 studies with acceptable methodological .…”